Gene description for Dnm1l
Gene name	dynamin 1-like
Gene symbol	Dnm1l
Other names/aliases	DLP1 Dnml1 Drp1
Species	Rattus norvegicus
Database cross references - Dnm1l
ExoCarta	ExoCarta_114114
Vesiclepedia	VP_114114
Entrez Gene	114114
UniProt	O35303
Dnm1l identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Dnm1l

Molecular Function     GTPase activity GO:0003924 IBA     GTPase activity GO:0003924 IEA     GTPase activity GO:0003924 ISO     GTPase activity GO:0003924 ISS     protein binding GO:0005515 IPI     GTP binding GO:0005525 IEA     microtubule binding GO:0008017 IBA     lipid binding GO:0008289 IEA     clathrin binding GO:0030276 IPI     GTP-dependent protein binding GO:0030742 ISO     small GTPase binding GO:0031267 ISO     ubiquitin protein ligase binding GO:0031625 ISO     identical protein binding GO:0042802 IPI     identical protein binding GO:0042802 ISO     protein homodimerization activity GO:0042803 ISO     protein homodimerization activity GO:0042803 ISS     protein-containing complex binding GO:0044877 IPI     BH2 domain binding GO:0051433 IPI     protein serine/threonine kinase binding GO:0120283 IPI     membrane scission GTPase motor activity GO:1990606 IEA Biological Process     mitochondrial fission GO:0000266 IBA     mitochondrial fission GO:0000266 ISO     mitochondrial fission GO:0000266 ISO     mitochondrial fission GO:0000266 ISS     calcium ion transport GO:0006816 ISO     endocytosis GO:0006897 IBA     mitochondrion organization GO:0007005 IMP     mitochondrion organization GO:0007005 ISO     mitochondrion organization GO:0007005 ISO     endoplasmic reticulum organization GO:0007029 ISO     regulation of gene expression GO:0010468 ISO     negative regulation of mitochondrial fusion GO:0010637 IMP     regulation of mitochondrion organization GO:0010821 ISO     peroxisome fission GO:0016559 IBA     peroxisome fission GO:0016559 ISO     peroxisome fission GO:0016559 ISS     response to endoplasmic reticulum stress GO:0034976 IMP     synaptic vesicle recycling via endosome GO:0036466 IMP     mitochondrial fragmentation involved in apoptotic process GO:0043653 IBA     mitochondrial fragmentation involved in apoptotic process GO:0043653 IMP     mitochondrial fragmentation involved in apoptotic process GO:0043653 ISO     intracellular distribution of mitochondria GO:0048312 IBA     intracellular distribution of mitochondria GO:0048312 IMP     intracellular distribution of mitochondria GO:0048312 ISO     synaptic vesicle endocytosis GO:0048488 IDA     synaptic vesicle endocytosis GO:0048488 IMP     rhythmic process GO:0048511 IEA     positive regulation of protein secretion GO:0050714 ISO     protein complex oligomerization GO:0051259 ISO     protein complex oligomerization GO:0051259 ISS     heart contraction GO:0060047 ISO     positive regulation of dendritic spine morphogenesis GO:0061003 IMP     protein localization to mitochondrion GO:0070585 ISO     protein localization to mitochondrion GO:0070585 ISO     cellular response to lipid GO:0071396 IEP     cellular response to hypoxia GO:0071456 IEP     positive regulation of neutrophil chemotaxis GO:0090023 ISO     positive regulation of mitochondrial fission GO:0090141 IMP     positive regulation of mitochondrial fission GO:0090141 ISO     mitochondrial membrane fission GO:0090149 ISO     mitocytosis GO:0160040 ISO     regulation of peroxisome organization GO:1900063 ISO     positive regulation of synaptic vesicle endocytosis GO:1900244 IMP     regulation of mitophagy GO:1901524 ISO     regulation of ATP metabolic process GO:1903578 ISO     regulation of ubiquitin protein ligase activity GO:1904666 ISO     response to flavonoid GO:1905395 IEP     response to hypobaric hypoxia GO:1990910 IEP     positive regulation of synaptic vesicle exocytosis GO:2000302 IMP Subcellular Localization     Golgi membrane GO:0000139 IDA     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 IEA     cytoplasm GO:0005737 ISO     mitochondrion GO:0005739 IBA     mitochondrion GO:0005739 ISO     mitochondrion GO:0005739 ISS     mitochondrial outer membrane GO:0005741 IEA     mitochondrial outer membrane GO:0005741 ISO     mitochondrial outer membrane GO:0005741 ISS     peroxisome GO:0005777 IDA     peroxisome GO:0005777 IEA     peroxisome GO:0005777 ISO     peroxisome GO:0005777 ISS     endoplasmic reticulum GO:0005783 IDA     endoplasmic reticulum GO:0005783 ISO     endoplasmic reticulum GO:0005783 ISO     Golgi apparatus GO:0005794 IEA     Golgi apparatus GO:0005794 ISO     cytosol GO:0005829 IDA     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     cytosol GO:0005829 ISS     microtubule GO:0005874 IBA     microtubule GO:0005874 ISO     plasma membrane GO:0005886 IDA     brush border GO:0005903 ISO     clathrin-coated pit GO:0005905 IDA     clathrin-coated pit GO:0005905 IEA     membrane GO:0016020 IBA     clathrin coat of trans-Golgi network vesicle GO:0030130 IDA     synaptic vesicle membrane GO:0030672 IDA     synaptic vesicle membrane GO:0030672 IEA     mitochondrial membrane GO:0031966 IDA     protein-containing complex GO:0032991 ISO     intracellular membrane-bounded organelle GO:0043231 ISO     perinuclear region of cytoplasm GO:0048471 IDA     perinuclear region of cytoplasm GO:0048471 ISO     presynaptic endocytic zone membrane GO:0098835 IDA     mitochondrion-derived vesicle GO:0099073 ISO     secretory vesicle GO:0099503 IDA