Gene description for Aco1
Gene name aconitase 1
Gene symbol Aco1
Other names/aliases Aco-1
Irebp
Irp1
Species Mus musculus
 Database cross references - Aco1
ExoCarta ExoCarta_11428
Vesiclepedia VP_11428
Entrez Gene 11428
UniProt P28271  
 Aco1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Aco1
Molecular Function
    RNA binding GO:0003723 ISO
    aconitate hydratase activity GO:0003994 IBA
    aconitate hydratase activity GO:0003994 IDA
    aconitate hydratase activity GO:0003994 ISO
    aconitate hydratase activity GO:0003994 ISS
    iron-responsive element binding GO:0030350 IBA
    iron-responsive element binding GO:0030350 IDA
    iron-responsive element binding GO:0030350 ISO
    iron-responsive element binding GO:0030350 ISS
    metal ion binding GO:0046872 IEA
    mRNA 5'-UTR binding GO:0048027 ISO
    iron-sulfur cluster binding GO:0051536 ISO
    3 iron, 4 sulfur cluster binding GO:0051538 IBA
    3 iron, 4 sulfur cluster binding GO:0051538 IEA
    3 iron, 4 sulfur cluster binding GO:0051538 ISO
    4 iron, 4 sulfur cluster binding GO:0051539 IBA
    4 iron, 4 sulfur cluster binding GO:0051539 ISO
    4 iron, 4 sulfur cluster binding GO:0051539 ISS
Biological Process
    tricarboxylic acid cycle GO:0006099 IBA
    tricarboxylic acid cycle GO:0006099 IEA
    citrate metabolic process GO:0006101 IBA
    citrate metabolic process GO:0006101 ISO
    citrate metabolic process GO:0006101 ISS
    regulation of translation GO:0006417 IMP
    intracellular iron ion homeostasis GO:0006879 IGI
    intracellular iron ion homeostasis GO:0006879 IMP
    intracellular iron ion homeostasis GO:0006879 ISO
    post-embryonic development GO:0009791 IGI
    response to iron(II) ion GO:0010040 ISO
    response to iron(II) ion GO:0010040 ISS
    regulation of gene expression GO:0010468 IGI
    intestinal absorption GO:0050892 IGI
Subcellular Localization
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISO
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 ISO
    endoplasmic reticulum GO:0005783 ISO
    Golgi apparatus GO:0005794 ISO
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Aco1 in sEVs
1
Experiment ID 907
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Aco1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fam120a  
Co-fractionation Mus musculus
2 Psmg1 56088
Co-fractionation Mus musculus
3 Nphp4  
Affinity Capture-MS Mus musculus
4 Strap 20901
Co-fractionation Mus musculus
5 Fubp1  
Co-fractionation Mus musculus
6 Spats2l 67198
Co-fractionation Mus musculus
View the network image/svg+xml



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