Gene description for Phb2
Gene name	prohibitin 2
Gene symbol	Phb2
Other names/aliases	Bap Bap-37 Bap37 Bcap27 Bcap37
Species	Rattus norvegicus
Database cross references - Phb2
ExoCarta	ExoCarta_114766
Vesiclepedia	VP_114766
Entrez Gene	114766
UniProt	Q5XIH7
Phb2 identified in sEVs derived from the following tissue/cell type
Adipocytes	25998041
Hepatocytes	19367702
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Phb2

Molecular Function     amide binding GO:0033218 IEA     amide binding GO:0033218 ISO     identical protein binding GO:0042802 ISO     protein homodimerization activity GO:0042803 IEA     protein homodimerization activity GO:0042803 ISO     protein homodimerization activity GO:0042803 ISS     sphingolipid binding GO:0046625 IEA     sphingolipid binding GO:0046625 ISO     sphingolipid binding GO:0046625 ISS     protein heterodimerization activity GO:0046982 IEA     protein heterodimerization activity GO:0046982 ISO Biological Process     mitophagy GO:0000423 IEA     mitophagy GO:0000423 ISO     mitophagy GO:0000423 ISS     positive regulation of immunoglobulin production GO:0002639 IEA     positive regulation of immunoglobulin production GO:0002639 ISO     positive regulation of immunoglobulin production GO:0002639 ISS     protein import into nucleus GO:0006606 IEA     protein import into nucleus GO:0006606 ISO     mitochondrion organization GO:0007005 IBA     mitochondrion organization GO:0007005 IEA     mitochondrion organization GO:0007005 ISO     sister chromatid cohesion GO:0007062 IEA     sister chromatid cohesion GO:0007062 ISO     cell migration GO:0016477 IEA     cell migration GO:0016477 ISO     cell migration GO:0016477 ISS     regulation of complement activation GO:0030449 ISO     estrogen receptor signaling pathway GO:0030520 IEA     estrogen receptor signaling pathway GO:0030520 ISO     positive regulation of exit from mitosis GO:0031536 IEA     positive regulation of exit from mitosis GO:0031536 ISO     negative regulation of intracellular estrogen receptor signaling pathway GO:0033147 IEA     negative regulation of intracellular estrogen receptor signaling pathway GO:0033147 ISO     mammary gland epithelial cell proliferation GO:0033598 IEA     mammary gland epithelial cell proliferation GO:0033598 ISO     negative regulation of mammary gland epithelial cell proliferation GO:0033600 IEA     negative regulation of mammary gland epithelial cell proliferation GO:0033600 ISO     RIG-I signaling pathway GO:0039529 IEA     RIG-I signaling pathway GO:0039529 ISO     B cell activation GO:0042113 IEA     B cell activation GO:0042113 ISO     B cell activation GO:0042113 ISS     negative regulation of apoptotic process GO:0043066 IEA     negative regulation of apoptotic process GO:0043066 IMP     negative regulation of apoptotic process GO:0043066 ISO     positive regulation of MAPK cascade GO:0043410 ISO     positive regulation of MAPK cascade GO:0043410 ISS     negative regulation of DNA-binding transcription factor activity GO:0043433 ISO     negative regulation of DNA-templated transcription GO:0045892 IEA     negative regulation of DNA-templated transcription GO:0045892 ISO     negative regulation of DNA-templated transcription GO:0045892 ISS     protein stabilization GO:0050821 IEA     protein stabilization GO:0050821 ISO     positive regulation of DNA-binding transcription factor activity GO:0051091 ISO     mammary gland branching involved in thelarche GO:0060744 IEA     mammary gland branching involved in thelarche GO:0060744 ISO     mammary gland alveolus development GO:0060749 IEA     mammary gland alveolus development GO:0060749 ISO     regulation of branching involved in mammary gland duct morphogenesis GO:0060762 IEA     regulation of branching involved in mammary gland duct morphogenesis GO:0060762 ISO     positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO     cellular response to retinoic acid GO:0071300 IEP     cellular response to hypoxia GO:0071456 IEP     antiviral innate immune response GO:0140374 IEA     antiviral innate immune response GO:0140374 ISO     regulation of cardiolipin metabolic process GO:1900208 IEA     regulation of cardiolipin metabolic process GO:1900208 ISO     regulation of cardiolipin metabolic process GO:1900208 ISS     positive regulation of non-canonical NF-kappaB signal transduction GO:1901224 IEA     positive regulation of non-canonical NF-kappaB signal transduction GO:1901224 ISO     positive regulation of non-canonical NF-kappaB signal transduction GO:1901224 ISS     positive regulation of cell cycle G1/S phase transition GO:1902808 IEA     positive regulation of cell cycle G1/S phase transition GO:1902808 ISO     regulation of cytochrome-c oxidase activity GO:1904959 ISO     regulation of cytochrome-c oxidase activity GO:1904959 ISS Subcellular Localization     nucleus GO:0005634 ISO     nucleus GO:0005634 ISS     cytoplasm GO:0005737 ISO     mitochondrion GO:0005739 IBA     mitochondrion GO:0005739 IDA     mitochondrion GO:0005739 ISO     mitochondrial outer membrane GO:0005741 IEA     mitochondrial outer membrane GO:0005741 ISO     mitochondrial inner membrane GO:0005743 IEA     mitochondrial inner membrane GO:0005743 ISO     mitochondrial inner membrane GO:0005743 ISS     plasma membrane GO:0005886 IEA     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISS     cell surface GO:0009986 IEA     cell surface GO:0009986 ISO     cell surface GO:0009986 ISS     postsynaptic density GO:0014069 EXP     postsynaptic density GO:0014069 IDA     nuclear matrix GO:0016363 IEA     nuclear matrix GO:0016363 ISO     nuclear matrix GO:0016363 ISS     axon GO:0030424 IDA     protein-containing complex GO:0032991 ISO     protein-containing complex GO:0032991 ISS     mitochondrial prohibitin complex GO:0035632 IEA     mitochondrial prohibitin complex GO:0035632 ISO     mitochondrial prohibitin complex GO:0035632 ISS     presynaptic active zone GO:0048786 EXP     presynaptic active zone GO:0048786 IDA     cell periphery GO:0071944 ISO     inner mitochondrial membrane protein complex GO:0098800 ISO     inner mitochondrial membrane protein complex GO:0098800 ISS     glutamatergic synapse GO:0098978 EXP     glutamatergic synapse GO:0098978 IDA     GABA-ergic synapse GO:0098982 EXP     GABA-ergic synapse GO:0098982 IDA