Gene description for GALNT13
Gene name polypeptide N-acetylgalactosaminyltransferase 13
Gene symbol GALNT13
Other names/aliases GalNAc-T13
Species Homo sapiens
 Database cross references - GALNT13
ExoCarta ExoCarta_114805
Vesiclepedia VP_114805
Entrez Gene 114805
HGNC 23242
MIM 608369
UniProt Q8IUC8  
 GALNT13 identified in sEVs derived from the following tissue/cell type
Prostate cancer cells 25844599    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for GALNT13
Molecular Function
    polypeptide N-acetylgalactosaminyltransferase activity GO:0004653 IBA
    polypeptide N-acetylgalactosaminyltransferase activity GO:0004653 IDA
    polypeptide N-acetylgalactosaminyltransferase activity GO:0004653 TAS
    carbohydrate binding GO:0030246 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    protein O-linked glycosylation GO:0006493 IBA
    O-glycan processing GO:0016266 TAS
    protein O-linked glycosylation via serine GO:0018242 IDA
    protein O-linked glycosylation via threonine GO:0018243 IDA
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    Golgi apparatus GO:0005794 IBA
 Experiment description of studies that identified GALNT13 in sEVs
1
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
2
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for GALNT13
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SMIM5  
Affinity Capture-MS Homo sapiens
2 COPS5 10987
Affinity Capture-MS Homo sapiens
3 GPIHBP1  
Affinity Capture-MS Homo sapiens
4 KLRC2  
Affinity Capture-MS Homo sapiens
5 KLRC3  
Affinity Capture-MS Homo sapiens
6 CD1A 909
Affinity Capture-MS Homo sapiens
7 TRAV20  
Affinity Capture-MS Homo sapiens
8 CANT1 124583
Affinity Capture-MS Homo sapiens
9 EXOSC2 23404
Two-hybrid Homo sapiens
10 SKIV2L 6499
Two-hybrid Homo sapiens
11 SCGB2A2  
Affinity Capture-MS Homo sapiens
12 GALNT1 2589
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 LRRC3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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