Gene description for Rims2
Gene name regulating synaptic membrane exocytosis 2
Gene symbol Rims2
Other names/aliases 2810036I15Rik
AW048769
RIM2
Rab3ip2
Rim2(+40A)
Rim2(+44A)
Rim2(+4A)
Serg2
Syt3-rs
mKIAA0751
Species Mus musculus
 Database cross references - Rims2
ExoCarta ExoCarta_116838
Vesiclepedia VP_116838
Entrez Gene 116838
UniProt Q9EQZ7  
 Rims2 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Rims2
Molecular Function
    protein binding GO:0005515 IPI
    protein domain specific binding GO:0019904 ISO
    protein-macromolecule adaptor activity GO:0030674 IDA
    protein-macromolecule adaptor activity GO:0030674 ISO
    small GTPase binding GO:0031267 IEA
    transmembrane transporter binding GO:0044325 IDA
    protein-containing complex binding GO:0044877 ISO
    metal ion binding GO:0046872 IEA
    structural constituent of presynaptic active zone GO:0098882 IBA
    structural constituent of presynaptic active zone GO:0098882 IDA
    structural constituent of presynaptic active zone GO:0098882 IEP
    structural constituent of presynaptic active zone GO:0098882 IMP
Biological Process
    intracellular protein transport GO:0006886 IEA
    adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 IDA
    neurotransmitter secretion GO:0007269 IGI
    positive regulation of gene expression GO:0010628 IGI
    synaptic vesicle docking GO:0016081 IBA
    synaptic vesicle docking GO:0016081 IDA
    synaptic vesicle docking GO:0016081 IMP
    synaptic vesicle priming GO:0016082 IBA
    synaptic vesicle priming GO:0016082 IDA
    synaptic vesicle priming GO:0016082 IMP
    calcium-ion regulated exocytosis GO:0017156 IDA
    regulation of exocytosis GO:0017157 IMP
    insulin secretion GO:0030073 IDA
    insulin secretion GO:0030073 IMP
    cell differentiation GO:0030154 IEA
    regulation of membrane potential GO:0042391 IDA
    maintenance of presynaptic active zone structure GO:0048790 IEA
    calcium ion-regulated exocytosis of neurotransmitter GO:0048791 IGI
    establishment of localization in cell GO:0051649 IMP
    spontaneous neurotransmitter secretion GO:0061669 IGI
    positive regulation of inhibitory postsynaptic potential GO:0097151 IGI
    regulation of calcium-dependent activation of synaptic vesicle fusion GO:0150037 IDA
    regulation of calcium-dependent activation of synaptic vesicle fusion GO:0150037 IMP
    positive regulation of dendrite extension GO:1903861 ISO
    regulation of synaptic vesicle exocytosis GO:2000300 IBA
    regulation of synaptic vesicle exocytosis GO:2000300 ISO
    positive regulation of excitatory postsynaptic potential GO:2000463 IGI
Subcellular Localization
    membrane GO:0016020 IEA
    protein-containing complex GO:0032991 ISO
    presynaptic membrane GO:0042734 IBA
    neuron projection GO:0043005 IEA
    inhibitory synapse GO:0060077 IMP
    photoreceptor ribbon synapse GO:0098684 ISO
    presynapse GO:0098793 IEA
    presynaptic active zone cytoplasmic component GO:0098831 IBA
    presynaptic active zone cytoplasmic component GO:0098831 ISO
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IMP
    GABA-ergic synapse GO:0098982 IDA
    GABA-ergic synapse GO:0098982 IMP
 Experiment description of studies that identified Rims2 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Rims2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Mipep  
Co-fractionation Mus musculus
2 Rab3a  
Affinity Capture-Western Mus musculus
3 Pclo  
Affinity Capture-Western Mus musculus
4 Rapgef4  
Affinity Capture-Western Mus musculus
5 Arsb  
Co-fractionation Mus musculus
6 Agap2  
Affinity Capture-MS Mus musculus
7 Xdh  
Co-fractionation Mus musculus
8 Ywhae 22627
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Rims2 is involved
No pathways found





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