Gene description for Crym
Gene name crystallin, mu
Gene symbol Crym
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Crym
ExoCarta ExoCarta_117024
Vesiclepedia VP_117024
Entrez Gene 117024
UniProt Q9QYU4  
 Crym identified in sEVs derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Crym
Molecular Function
    transcription corepressor activity GO:0003714 ISO
    hormone binding GO:0042562 IEA
    hormone binding GO:0042562 ISO
    protein homodimerization activity GO:0042803 ISO
    thiomorpholine-carboxylate dehydrogenase activity GO:0047127 IEA
    thiomorpholine-carboxylate dehydrogenase activity GO:0047127 ISO
    NADP binding GO:0050661 ISO
    thyroid hormone binding GO:0070324 IBA
    thyroid hormone binding GO:0070324 ISO
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 ISO
    mitochondrial transport GO:0006839 IDA
    sensory perception of sound GO:0007605 ISO
    response to hormone GO:0009725 IEP
    response to vitamin D GO:0033280 IEP
    thyroid hormone metabolic process GO:0042403 IBA
    thyroid hormone metabolic process GO:0042403 IEA
    thyroid hormone metabolic process GO:0042403 ISO
    thyroid hormone transport GO:0070327 ISO
Subcellular Localization
    nucleus GO:0005634 IEA
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISO
    mitochondrion GO:0005739 IEA
    mitochondrion GO:0005739 ISO
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Crym in sEVs
1
Experiment ID 192
MISEV standards
CEM
Biophysical techniques
TSG101|HSP70|CD63|CD81|FLOT
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M."
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Crym
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Mib1  
Affinity Capture-MS Rattus norvegicus
2 Itm2b 290364
Affinity Capture-MS Rattus norvegicus
View the network image/svg+xml
 Pathways in which Crym is involved
PathwayEvidenceSource
Lysine catabolism IEA Reactome
Metabolism IEA Reactome
Metabolism of amino acids and derivatives IEA Reactome





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