Gene description for Cp
Gene name ceruloplasmin
Gene symbol Cp
Other names/aliases D3Ertd555e
Species Mus musculus
 Database cross references - Cp
ExoCarta ExoCarta_12870
Vesiclepedia VP_12870
Entrez Gene 12870
UniProt Q61147  
 Cp identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Cp
Molecular Function
    ferroxidase activity GO:0004322 IDA
    ferroxidase activity GO:0004322 ISO
    ferroxidase activity GO:0004322 ISS
    glutathione peroxidase activity GO:0004602 ISO
    glutathione peroxidase activity GO:0004602 ISS
    copper ion binding GO:0005507 IDA
    copper ion binding GO:0005507 ISO
    oxidoreductase activity GO:0016491 IBA
    oxidoreductase activity, acting on metal ions, oxygen as acceptor GO:0016724 ISO
    oxidoreductase activity, acting on metal ions, oxygen as acceptor GO:0016724 ISS
    phospholipid-hydroperoxide glutathione peroxidase activity GO:0047066 ISO
    phospholipid-hydroperoxide glutathione peroxidase activity GO:0047066 ISS
    protein-folding chaperone binding GO:0051087 ISO
Biological Process
    iron ion transport GO:0006826 IBA
    intracellular copper ion homeostasis GO:0006878 ISO
    intracellular copper ion homeostasis GO:0006878 ISS
    intracellular iron ion homeostasis GO:0006879 ISO
    intracellular iron ion homeostasis GO:0006879 ISS
    response to copper ion GO:0046688 ISO
    cellular oxidant detoxification GO:0098869 IEA
Subcellular Localization
    extracellular space GO:0005615 HDA
    extracellular space GO:0005615 IDA
    extracellular space GO:0005615 ISO
    extracellular space GO:0005615 ISS
    plasma membrane GO:0005886 IBA
    cell surface GO:0009986 ISO
 Experiment description of studies that identified Cp in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Cp
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Apoa1 11806
Co-fractionation Mus musculus
2 Fancd2  
Affinity Capture-MS Mus musculus
View the network image/svg+xml



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