Gene description for LYPD6B
Gene name LY6/PLAUR domain containing 6B
Gene symbol LYPD6B
Other names/aliases CT116
LYPD7
Species Homo sapiens
 Database cross references - LYPD6B
ExoCarta ExoCarta_130576
Vesiclepedia VP_130576
Entrez Gene 130576
HGNC 27018
UniProt Q8NI32  
 LYPD6B identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for LYPD6B
Molecular Function
    acetylcholine receptor regulator activity GO:0030548 IBA
    acetylcholine receptor regulator activity GO:0030548 IDA
Subcellular Localization
    extracellular region GO:0005576 TAS
    plasma membrane GO:0005886 TAS
    side of membrane GO:0098552 IEA
 Experiment description of studies that identified LYPD6B in sEVs
1
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for LYPD6B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBR2 23304
Affinity Capture-MS Homo sapiens
2 ZMYM4  
Affinity Capture-MS Homo sapiens
3 COL6A1 1291
Affinity Capture-MS Homo sapiens
4 UGGT2 55757
Affinity Capture-MS Homo sapiens
5 ADAMTS7  
Affinity Capture-MS Homo sapiens
6 MYCBP2 23077
Affinity Capture-MS Homo sapiens
7 LAMB2 3913
Affinity Capture-MS Homo sapiens
8 UBR4 23352
Affinity Capture-MS Homo sapiens
9 KCMF1 56888
Affinity Capture-MS Homo sapiens
10 TUBB8 347688
Affinity Capture-MS Homo sapiens
11 TRIM7  
Affinity Capture-MS Homo sapiens
12 FBLN1 2192
Affinity Capture-MS Homo sapiens
13 ERGIC1 57222
Affinity Capture-MS Homo sapiens
14 ERP44 23071
Affinity Capture-MS Homo sapiens
15 SEMA3B 7869
Affinity Capture-MS Homo sapiens
16 AMY1C 278
Affinity Capture-MS Homo sapiens
17 IDE 3416
Affinity Capture-MS Homo sapiens
18 ZNF195  
Affinity Capture-MS Homo sapiens
19 DCAF6 55827
Affinity Capture-MS Homo sapiens
20 VWDE  
Affinity Capture-MS Homo sapiens
21 CST4 1472
Affinity Capture-MS Homo sapiens
22 SEC11A 23478
Affinity Capture-MS Homo sapiens
23 UBR1 197131
Affinity Capture-MS Homo sapiens
24 CHRD  
Affinity Capture-MS Homo sapiens
25 TCAF1 9747
Affinity Capture-MS Homo sapiens
26 CDK5RAP3 80279
Affinity Capture-MS Homo sapiens
27 PLXDC2 84898
Affinity Capture-MS Homo sapiens
28 MIB2 142678
Affinity Capture-MS Homo sapiens
29 VMA21  
Two-hybrid Homo sapiens
30 FCGBP 8857
Affinity Capture-MS Homo sapiens
31 PRPS1 5631
Affinity Capture-MS Homo sapiens
32 MKLN1  
Affinity Capture-MS Homo sapiens
33 TIMP2 7077
Affinity Capture-MS Homo sapiens
34 SPCS2 9789
Affinity Capture-MS Homo sapiens
35 TUBB7P 56604
Affinity Capture-MS Homo sapiens
36 PSME4 23198
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here