Gene description for CR1
Gene name	complement component (3b/4b) receptor 1 (Knops blood group)
Gene symbol	CR1
Other names/aliases	C3BR C4BR CD35 KN
Species	Homo sapiens
Database cross references - CR1
ExoCarta	ExoCarta_1378
Vesiclepedia	VP_1378
Entrez Gene	1378
HGNC	2334
MIM	120620
UniProt	P17927
CR1 identified in sEVs derived from the following tissue/cell type
Urine	15326289
Urine	19056867
Urine	22418980
Urine	22418980

Gene ontology annotations for CR1

Molecular Function     virus receptor activity GO:0001618 IEA     complement component C3b binding GO:0001851 IDA     complement component C4b binding GO:0001855 IDA     complement component C4b receptor activity GO:0001861 IDA     complement component C3b receptor activity GO:0004877 IDA     protein binding GO:0005515 IPI Biological Process     positive regulation of activation of membrane attack complex GO:0001970 IMP     negative regulation of activation of membrane attack complex GO:0001971 IDA     complement receptor mediated signaling pathway GO:0002430 IDA     immune complex clearance by erythrocytes GO:0002435 IDA     T cell mediated immunity GO:0002456 IBA     negative regulation of immunoglobulin production GO:0002638 IDA     complement activation, alternative pathway GO:0006957 IMP     complement activation, classical pathway GO:0006958 IEA     plasma membrane organization GO:0007009 IDA     positive regulation of cell population proliferation GO:0008284 IDA     negative regulation of type II interferon production GO:0032689 IDA     negative regulation of interleukin-2 production GO:0032703 IDA     negative regulation of T cell proliferation GO:0042130 IDA     positive regulation of regulatory T cell differentiation GO:0045591 IDA     negative regulation of complement activation GO:0045916 IDA     negative regulation of complement activation, alternative pathway GO:0045957 IDA     negative regulation of complement activation, classical pathway GO:0045959 IBA     negative regulation of complement activation, classical pathway GO:0045959 IDA     symbiont entry into host cell GO:0046718 IEA     negative regulation of serine-type endopeptidase activity GO:1900004 IDA     positive regulation of serine-type endopeptidase activity GO:1900005 IDA     negative regulation of plasma cell differentiation GO:1900099 IDA     negative regulation of complement-dependent cytotoxicity GO:1903660 IDA     ATP export GO:1904669 IDA Subcellular Localization     extracellular space GO:0005615 IBA     cytoskeleton GO:0005856 IDA     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 TAS     cell surface GO:0009986 IDA     secretory granule membrane GO:0030667 TAS     plasma membrane raft GO:0044853 IDA     extracellular exosome GO:0070062 HDA     ficolin-1-rich granule membrane GO:0101003 TAS