Gene description for ASB6
Gene name ankyrin repeat and SOCS box containing 6
Gene symbol ASB6
Other names/aliases -
Species Homo sapiens
 Database cross references - ASB6
ExoCarta ExoCarta_140459
Vesiclepedia VP_140459
Entrez Gene 140459
HGNC 17181
MIM 615051
UniProt Q9NWX5  
 ASB6 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for ASB6
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    protein ubiquitination GO:0016567 IEA
    intracellular signal transduction GO:0035556 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
 Experiment description of studies that identified ASB6 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ASB6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 POLR2B 5431
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 POLR2G 5436
Affinity Capture-MS Homo sapiens
3 ABCF3 55324
Affinity Capture-MS Homo sapiens
4 C6orf62 81688
Affinity Capture-MS Homo sapiens
5 TCEB1 6921
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 OGFOD1  
Co-fractionation Homo sapiens
7 FAM9B  
Two-hybrid Homo sapiens
8 CORO7 79585
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 FAM168A  
Affinity Capture-MS Homo sapiens
10 ANKS1A 23294
Affinity Capture-MS Homo sapiens
11 APP 351
Reconstituted Complex Homo sapiens
12 COPS5 10987
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 DDA1  
Affinity Capture-MS Homo sapiens
14 COPS6 10980
Affinity Capture-MS Homo sapiens
15 POLR2I 5438
Affinity Capture-MS Homo sapiens
16 E2F6 1876
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 METAP2 10988
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 MCTS1 28985
Co-fractionation Homo sapiens
19 POLR2C 5432
Affinity Capture-MS Homo sapiens
20 POLR2M  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 ARIH2 10425
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 GPS1 2873
Affinity Capture-MS Homo sapiens
23 GPN3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 NF2 4771
Negative Genetic Homo sapiens
25 RNF41  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
26 UXT 8409
Affinity Capture-MS Homo sapiens
27 RBX1 9978
Affinity Capture-MS Homo sapiens
28 CUL4B 8450
Affinity Capture-MS Homo sapiens
29 MOS 4342
Two-hybrid Homo sapiens
30 FGA 2243
Affinity Capture-MS Homo sapiens
31 CADPS2  
Affinity Capture-MS Homo sapiens
32 HIF1AN 55662
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 PDXDC1 23042
Affinity Capture-MS Homo sapiens
34 SH2B2  
Two-hybrid Homo sapiens
35 FGG 2266
Affinity Capture-MS Homo sapiens
36 TARS2 80222
Two-hybrid Homo sapiens
37 ZNF655  
Two-hybrid Homo sapiens
38 S100B 6285
Affinity Capture-MS Homo sapiens
39 NMT2 9397
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 COPS3 8533
Affinity Capture-MS Homo sapiens
41 ARAP3 64411
Affinity Capture-MS Homo sapiens
42 L3MBTL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 COPS7B 64708
Affinity Capture-MS Homo sapiens
44 MTMR4  
Affinity Capture-MS Homo sapiens
45 DUSP23 54935
Two-hybrid Homo sapiens
46 UBXN6 80700
Affinity Capture-MS Homo sapiens
47 TCAP  
Two-hybrid Homo sapiens
48 UBR2 23304
Affinity Capture-MS Homo sapiens
49 RECQL5  
Affinity Capture-MS Homo sapiens
50 DCXR 51181
Affinity Capture-MS Homo sapiens
51 COPS2 9318
Affinity Capture-MS Homo sapiens
52 COPS7A 50813
Affinity Capture-MS Homo sapiens
53 MGA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 HOXB5  
Two-hybrid Homo sapiens
55 CUL3 8452
Affinity Capture-MS Homo sapiens
56 RPRD1A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 POLR2D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 POLR2A 5430
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
59 L3MBTL3  
Two-hybrid Homo sapiens
60 DCUN1D1 54165
Affinity Capture-MS Homo sapiens
61 GNB2 2783
Affinity Capture-MS Homo sapiens
62 FH 2271
Co-fractionation Homo sapiens
63 TCEB2 6923
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 ZNF587  
Two-hybrid Homo sapiens
65 KIF2B 84643
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 ATIC 471
Co-fractionation Homo sapiens
67 PROSC 11212
Co-fractionation Homo sapiens
68 ASB3 51130
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
69 POLR2F  
Affinity Capture-MS Homo sapiens
70 HDGF 3068
Co-fractionation Homo sapiens
71 POLR2J  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 RAD17  
Affinity Capture-MS Homo sapiens
73 HOMEZ  
Two-hybrid Homo sapiens
74 POLR2L 5441
Affinity Capture-MS Homo sapiens
75 Dync1li1 235661
Affinity Capture-MS Mus musculus
76 EZR 7430
Co-fractionation Homo sapiens
77 CUL5 8065
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 FGB 2244
Affinity Capture-MS Homo sapiens
79 RPAP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 HSPB1 3315
Affinity Capture-MS Homo sapiens
81 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
82 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
83 TBC1D2B 23102
Affinity Capture-MS Homo sapiens
84 RNF7  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 PHLDA1 22822
Affinity Capture-MS Homo sapiens
86 RPRD1B 58490
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 ZBTB42  
Two-hybrid Homo sapiens
88 COPS4 51138
Affinity Capture-MS Homo sapiens
89 CHRNB1  
Two-hybrid Homo sapiens
90 SLC25A5 292
Affinity Capture-MS Homo sapiens
91 PDRG1  
Affinity Capture-MS Homo sapiens
92 XPNPEP1 7511
Co-fractionation Homo sapiens
View the network image/svg+xml



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