Gene description for CSN1S1
Gene name casein alpha s1
Gene symbol CSN1S1
Other names/aliases CASA
CSN1
Species Homo sapiens
 Database cross references - CSN1S1
ExoCarta ExoCarta_1446
Vesiclepedia VP_1446
Entrez Gene 1446
HGNC 2445
MIM 115450
UniProt P47710  
 CSN1S1 identified in sEVs derived from the following tissue/cell type
Breast milk 17641064    
Breast milk 17641064    
 Gene ontology annotations for CSN1S1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    response to estradiol GO:0032355 IBA
    response to progesterone GO:0032570 IBA
    response to dehydroepiandrosterone GO:1903494 IBA
    response to 11-deoxycorticosterone GO:1903496 IBA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 HDA
    extracellular space GO:0005615 IBA
 Experiment description of studies that identified CSN1S1 in sEVs
1
Experiment ID 46
MISEV standards
✔
EM|IEM
Biophysical techniques
✔
HSC70|CD63|MHCII|CD81|CD86
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17641064    
Organism Homo sapiens
Experiment description Exosomes with immune modulatory features are present in human breast milk.
Authors "Admyre C, Johansson SM, Qazi KR, Filen JJ, Lahesmaa R, Norman M, Neve EP, Scheynius A, Gabrielsson S"
Journal name JIMMU
Publication year 2007
Sample Breast milk
Sample name Breast milk - Colostrum
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density 1.10-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
FACS
2
Experiment ID 48
MISEV standards
✔
EM|IEM
Biophysical techniques
✔
HSC70|CD63|CD86|MHCII
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17641064    
Organism Homo sapiens
Experiment description Exosomes with immune modulatory features are present in human breast milk.
Authors "Admyre C, Johansson SM, Qazi KR, Filen JJ, Lahesmaa R, Norman M, Neve EP, Scheynius A, Gabrielsson S"
Journal name JIMMU
Publication year 2007
Sample Breast milk
Sample name Breast milk - Mature milk
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density 1.10-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
FACS
 Protein-protein interactions for CSN1S1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CUL1 8454
Affinity Capture-Western Homo sapiens
2 HSPA5 3309
Affinity Capture-MS Homo sapiens
3 KLHL15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 CSNK2B 1460
Reconstituted Complex Homo sapiens
5 COPS7A 50813
Affinity Capture-MS Homo sapiens
6 FAM120A 23196
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 MAN2B2 23324
Affinity Capture-MS Homo sapiens
8 UBQLN2 29978
Two-hybrid Homo sapiens
9 TOLLIP 54472
Two-hybrid Homo sapiens
10 CDKN2AIP  
Affinity Capture-MS Homo sapiens
11 PRSS2 5645
Biochemical Activity Homo sapiens
12 NHLRC2 374354
Affinity Capture-MS Homo sapiens
13 CSNK2A1 1457
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
14 PARK7 11315
Biochemical Activity Homo sapiens
15 NXT2  
Affinity Capture-MS Homo sapiens
16 PDE10A 10846
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 DCAF8 50717
Affinity Capture-MS Homo sapiens
18 ERF  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 LMF1 64788
Affinity Capture-MS Homo sapiens
20 EMILIN3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 PLK1 5347
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
22 COPS5 10987
Affinity Capture-MS Homo sapiens
23 ETV3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 LTBP1 4052
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 TIMP3 7078
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 CUL4A 8451
Affinity Capture-Western Homo sapiens
27 B4GALNT4  
Affinity Capture-MS Homo sapiens
28 BCOR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CSN1S1 is involved
PathwayEvidenceSource
Miscellaneous transport and binding events TAS Reactome
Transport of small molecules TAS Reactome





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