Gene description for PM20D1
Gene name peptidase M20 domain containing 1
Gene symbol PM20D1
Other names/aliases Cps1
Species Homo sapiens
 Database cross references - PM20D1
ExoCarta ExoCarta_148811
Vesiclepedia VP_148811
Entrez Gene 148811
HGNC 26518
UniProt Q6GTS8  
 PM20D1 identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for PM20D1
Molecular Function
    aminoacylase activity GO:0004046 IEA
    peptidase activity GO:0008233 IEA
    hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0016811 EXP
    hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0016811 IBA
    lyase activity GO:0016829 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    proteolysis GO:0006508 IEA
    amino acid metabolic process GO:0006520 IBA
    amino acid metabolic process GO:0006520 IDA
    lipid metabolic process GO:0006629 IBA
    lipid metabolic process GO:0006629 IDA
    fatty acid metabolic process GO:0006631 IEA
    amide biosynthetic process GO:0043604 IBA
    amide biosynthetic process GO:0043604 IDA
    amide catabolic process GO:0043605 IBA
    amide catabolic process GO:0043605 IDA
    energy homeostasis GO:0097009 IEA
    adaptive thermogenesis GO:1990845 TAS
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified PM20D1 in sEVs
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for PM20D1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SH2D3A  
Affinity Capture-MS Homo sapiens
2 PDE4DIP 9659
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 MBD4  
Affinity Capture-MS Homo sapiens
4 MRM1  
Affinity Capture-MS Homo sapiens
5 PCP4  
Affinity Capture-MS Homo sapiens
6 UPK1A 11045
Affinity Capture-MS Homo sapiens
7 NPPA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 PINK1  
Affinity Capture-MS Homo sapiens
9 NT5C1A  
Affinity Capture-MS Homo sapiens
10 ST7  
Affinity Capture-MS Homo sapiens
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