Gene description for SH3D19
Gene name SH3 domain containing 19
Gene symbol SH3D19
Other names/aliases EBP
EVE1
Kryn
SH3P19
Species Homo sapiens
 Database cross references - SH3D19
ExoCarta ExoCarta_152503
Vesiclepedia VP_152503
Entrez Gene 152503
HGNC 30418
MIM 608674
UniProt Q5HYK7  
 SH3D19 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SH3D19
Molecular Function
    protein binding GO:0005515 IPI
    proline-rich region binding GO:0070064 IPI
Biological Process
    cytoskeleton organization GO:0007010 IMP
    regulation of cell morphogenesis GO:0022604 IMP
    positive regulation of membrane protein ectodomain proteolysis GO:0051044 IMP
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified SH3D19 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SH3D19
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 AP2B1 163
Proximity Label-MS Homo sapiens
2 GRB2 2885
Two-hybrid Homo sapiens
3 Cd2ap 12488
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
4 Terf2  
Affinity Capture-MS Mus musculus
5 SH3YL1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
6 PFN1 5216
Proximity Label-MS Homo sapiens
7 CLTA 1211
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 EZR 7430
Proximity Label-MS Homo sapiens
9 SH3RF1  
Two-hybrid Homo sapiens
10 YWHAZ 7534
Affinity Capture-MS Homo sapiens
11 PRPH 5630
Proximity Label-MS Homo sapiens
12 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
13 WWP2 11060
Affinity Capture-MS Homo sapiens
14 CXADR 1525
Proximity Label-MS Homo sapiens
15 CLTB 1212
Proximity Label-MS Homo sapiens
16 LYN 4067
Proximity Label-MS Homo sapiens
17 MAPRE1 22919
Proximity Label-MS Homo sapiens
18 CDC42 998
Two-hybrid Homo sapiens
19 RAB5A 5868
Proximity Label-MS Homo sapiens
20 MAPRE3  
Proximity Label-MS Homo sapiens
21 KDM1A 23028
Proximity Label-MS Homo sapiens
22 RDX 5962
Proximity Label-MS Homo sapiens
23 TBRG4 9238
Proximity Label-MS Homo sapiens
24 YWHAE 7531
Affinity Capture-MS Homo sapiens
25 ACTR3 10096
Proximity Label-MS Homo sapiens
26 MB21D1  
Proximity Label-MS Homo sapiens
27 DCTN1 1639
Proximity Label-MS Homo sapiens
28 CDH1 999
Proximity Label-MS Homo sapiens
29 IMPDH2 3615
Proximity Label-MS Homo sapiens
30 PTPN23 25930
Proximity Label-MS Homo sapiens
31 ACTB 60
Proximity Label-MS Homo sapiens
32 SH3KBP1 30011
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 DNM2 1785
Affinity Capture-MS Homo sapiens
34 CAPZB 832
Affinity Capture-MS Homo sapiens
35 RHOB 388
Proximity Label-MS Homo sapiens
36 OCLN 100506658
Proximity Label-MS Homo sapiens
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