Gene description for DAB2IP
Gene name DAB2 interacting protein
Gene symbol DAB2IP
Other names/aliases AF9Q34
AIP-1
AIP1
DIP1/2
Species Homo sapiens
 Database cross references - DAB2IP
ExoCarta ExoCarta_153090
Vesiclepedia VP_153090
Entrez Gene 153090
HGNC 17294
MIM 609205
UniProt Q5VWQ8  
 DAB2IP identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for DAB2IP
Molecular Function
    GTPase activator activity GO:0005096 IEA
    death receptor binding GO:0005123 IPI
    protein binding GO:0005515 IPI
    SH3 domain binding GO:0017124 IDA
    kinase binding GO:0019900 IPI
    protein kinase binding GO:0019901 IDA
    protein kinase binding GO:0019901 IPI
    mitogen-activated protein kinase kinase binding GO:0031434 IPI
    mitogen-activated protein kinase kinase kinase binding GO:0031435 IPI
    phosphatidylinositol-3-phosphate binding GO:0032266 IDA
    signaling adaptor activity GO:0035591 IDA
    Toll-like receptor 4 binding GO:0035662 IDA
    phosphatidylinositol 3-kinase regulatory subunit binding GO:0036312 IDA
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 IPI
    vascular endothelial growth factor receptor 2 binding GO:0043184 IPI
    protein serine/threonine kinase activator activity GO:0043539 IDA
    phosphatidylinositol 3-kinase binding GO:0043548 IDA
    protein-containing complex binding GO:0044877 IDA
    cadherin binding GO:0045296 HDA
    protein phosphatase 2A binding GO:0051721 IDA
    phosphatidylinositol-4-phosphate binding GO:0070273 IDA
    14-3-3 protein binding GO:0071889 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    negative regulation of transcription by RNA polymerase II GO:0000122 IMP
    angiogenesis GO:0001525 IEA
    inflammatory response GO:0006954 IEA
    negative regulation of cell population proliferation GO:0008285 IDA
    extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 IMP
    negative regulation of endothelial cell migration GO:0010596 IMP
    negative regulation of epithelial cell migration GO:0010633 IMP
    negative regulation of epithelial cell migration GO:0010633 TAS
    negative regulation of epithelial to mesenchymal transition GO:0010719 IDA
    negative regulation of epithelial to mesenchymal transition GO:0010719 IMP
    positive regulation of neuron projection development GO:0010976 ISS
    negative regulation of angiogenesis GO:0016525 IDA
    cell motility involved in cerebral cortex radial glia guided migration GO:0021814 ISS
    layer formation in cerebral cortex GO:0021819 ISS
    protein catabolic process GO:0030163 IDA
    negative regulation of vascular endothelial growth factor receptor signaling pathway GO:0030948 IMP
    positive regulation of protein-containing complex assembly GO:0031334 IDA
    negative regulation of NF-kappaB transcription factor activity GO:0032088 IMP
    negative regulation of toll-like receptor 4 signaling pathway GO:0034144 IDA
    negative regulation of GTPase activity GO:0034260 IMP
    negative regulation of GTPase activity GO:0034260 ISS
    cellular response to unfolded protein GO:0034620 TAS
    tube formation GO:0035148 IMP
    intracellular signal transduction GO:0035556 IMP
    cellular response to vascular endothelial growth factor stimulus GO:0035924 IDA
    cellular response to vascular endothelial growth factor stimulus GO:0035924 ISS
    vascular endothelial growth factor receptor-2 signaling pathway GO:0036324 ISS
    negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 ISS
    negative regulation of protein catabolic process GO:0042177 IDA
    positive regulation of apoptotic process GO:0043065 IDA
    regulation of GTPase activity GO:0043087 ISS
    regulation of canonical NF-kappaB signal transduction GO:0043122 ISS
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 ISS
    negative regulation of canonical NF-kappaB signal transduction GO:0043124 IDA
    regulation of protein-containing complex assembly GO:0043254 IDA
    negative regulation of MAP kinase activity GO:0043407 IDA
    negative regulation of MAP kinase activity GO:0043407 IMP
    positive regulation of MAPK cascade GO:0043410 IDA
    positive regulation of JUN kinase activity GO:0043507 IDA
    innate immune response GO:0045087 IEA
    positive regulation of protein catabolic process GO:0045732 ISS
    negative regulation of DNA-templated transcription GO:0045892 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of JNK cascade GO:0046330 IDA
    negative regulation of Ras protein signal transduction GO:0046580 IC
    negative regulation of fibroblast proliferation GO:0048147 ISS
    neuron projection morphogenesis GO:0048812 ISS
    negative regulation of epithelial cell proliferation GO:0050680 IMP
    regulation of cell cycle GO:0051726 IDA
    negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051898 IDA
    intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 ISS
    negative regulation of G0 to G1 transition GO:0070317 IDA
    negative regulation of ERK1 and ERK2 cascade GO:0070373 IDA
    cellular response to lipopolysaccharide GO:0071222 IDA
    cellular response to interleukin-1 GO:0071347 IDA
    cellular response to tumor necrosis factor GO:0071356 IDA
    cellular response to epidermal growth factor stimulus GO:0071364 ISS
    negative regulation of protein serine/threonine kinase activity GO:0071901 IMP
    positive regulation of protein serine/threonine kinase activity GO:0071902 IMP
    endothelial cell apoptotic process GO:0072577 TAS
    negative regulation of canonical Wnt signaling pathway GO:0090090 IMP
    negative regulation of canonical Wnt signaling pathway GO:0090090 ISS
    positive regulation of synapse maturation GO:0090129 ISS
    positive regulation of dendrite development GO:1900006 ISS
    regulation of p38MAPK cascade GO:1900744 ISS
    negative regulation of vascular endothelial growth factor signaling pathway GO:1900747 ISS
    positive regulation of proteasomal protein catabolic process GO:1901800 IMP
    positive regulation of IRE1-mediated unfolded protein response GO:1903896 TAS
    positive regulation of neuron migration GO:2001224 ISS
    positive regulation of apoptotic signaling pathway GO:2001235 IDA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IDA
    endocytic vesicle GO:0030139 IDA
    axon GO:0030424 ISS
    dendrite GO:0030425 IEA
    neuronal cell body membrane GO:0032809 ISS
    neuronal cell body GO:0043025 ISS
    cerebellar mossy fiber GO:0044300 ISS
    climbing fiber GO:0044301 ISS
    parallel fiber GO:1990032 ISS
    AIP1-IRE1 complex GO:1990597 IDA
 Experiment description of studies that identified DAB2IP in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for DAB2IP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAB 7529
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 YWHAE 7531
Affinity Capture-MS Homo sapiens
3 ANKS1B 56899
Affinity Capture-MS Homo sapiens
4 CUL1 8454
Affinity Capture-Western Homo sapiens
5 LYN 4067
Proximity Label-MS Homo sapiens
6 SKP1 6500
Affinity Capture-Western Homo sapiens
7 RAB35 11021
Proximity Label-MS Homo sapiens
8 Cdk1 12534
Affinity Capture-MS Mus musculus
9 RNASEH2B  
Affinity Capture-MS Homo sapiens
10 RAB4B 53916
Affinity Capture-MS Homo sapiens
11 TRAF2 7186
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
12 DAB2 1601
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
13 MAD2L1 4085
Affinity Capture-Western Homo sapiens
14 OCLN 100506658
Proximity Label-MS Homo sapiens
15 FBXW7  
Affinity Capture-Western Homo sapiens
16 TP53 7157
Affinity Capture-Western Homo sapiens
17 XPO1 7514
Affinity Capture-MS Homo sapiens
18 CD83  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 MCC 4163
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 UGGT1 56886
Affinity Capture-MS Homo sapiens
21 RFPL3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 TMEM206 55248
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 TNFRSF1A 7132
Affinity Capture-Western Homo sapiens
24 CLEC4A  
Affinity Capture-MS Homo sapiens
25 HRAS 3265
Affinity Capture-Western Homo sapiens
26 TRADD 8717
Affinity Capture-Western Homo sapiens
27 EFNB1 1947
Affinity Capture-MS Homo sapiens
28 RBX1 9978
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
29 EXOSC9 5393
Affinity Capture-MS Homo sapiens
30 Shoc2  
Affinity Capture-MS Mus musculus
31 CBY1  
Affinity Capture-MS Homo sapiens
32 RIPK1 8737
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
33 ANKS1A 23294
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 C11orf52 91894
Proximity Label-MS Homo sapiens
35 TP73  
Affinity Capture-Western Homo sapiens
36 Cep152  
Affinity Capture-MS Mus musculus
37 MAP3K5 4217
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
38 EPHA2 1969
Proximity Label-MS Homo sapiens
39 IWS1  
Affinity Capture-MS Homo sapiens
40 CDH1 999
Proximity Label-MS Homo sapiens
41 YWHAZ 7534
Affinity Capture-MS Homo sapiens
42 CSNK1A1 1452
Affinity Capture-MS Homo sapiens
43 SNX17 9784
Affinity Capture-MS Homo sapiens
44 NTRK1 4914
Affinity Capture-MS Homo sapiens
45 YWHAH 7533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 CDC20 991
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
47 TP63  
Affinity Capture-Western Homo sapiens
48 PLK1 5347
Affinity Capture-Western Homo sapiens
49 TMEM9 252839
Affinity Capture-MS Homo sapiens
50 Mis12  
Affinity Capture-MS Mus musculus
51 CGN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 YWHAQ 10971
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
53 KRAS 3845
Proximity Label-MS Homo sapiens
54 RHOB 388
Proximity Label-MS Homo sapiens
55 CLIP1 6249
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 YWHAG 7532
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 SLC31A1 1317
Affinity Capture-MS Homo sapiens
58 ASXL2  
Affinity Capture-MS Homo sapiens
59 AKT1 207
Biochemical Activity Homo sapiens
60 RASAL2 9462
Affinity Capture-MS Homo sapiens
61 CTDSPL 10217
Proximity Label-MS Homo sapiens
62 DDX3Y 8653
Affinity Capture-MS Homo sapiens
63 CUL4A 8451
Affinity Capture-Western Homo sapiens
64 BUB1B  
Affinity Capture-Western Homo sapiens
65 CDC27 996
Affinity Capture-Western Homo sapiens
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