Gene description for Il17ra
Gene name interleukin 17 receptor A
Gene symbol Il17ra
Other names/aliases AW538159
Cdw217
Il17r
VDw217
Species Mus musculus
 Database cross references - Il17ra
ExoCarta ExoCarta_16172
Vesiclepedia VP_16172
Entrez Gene 16172
UniProt Q60943  
 Il17ra identified in sEVs derived from the following tissue/cell type
Breast cancer cells 34112803    
Breast cancer cells 34112803    
 Gene ontology annotations for Il17ra
Molecular Function
    signaling receptor binding GO:0005102 IPI
    protein binding GO:0005515 IPI
    interleukin-17 receptor activity GO:0030368 IBA
    interleukin-17 receptor activity GO:0030368 IDA
    interleukin-17 receptor activity GO:0030368 ISO
Biological Process
    inflammatory response GO:0006954 IEA
    response to virus GO:0009615 IDA
    response to virus GO:0009615 ISO
    protein catabolic process GO:0030163 IDA
    positive regulation of interleukin-13 production GO:0032736 IMP
    positive regulation of interleukin-23 production GO:0032747 IEA
    positive regulation of interleukin-23 production GO:0032747 ISO
    positive regulation of interleukin-5 production GO:0032754 IMP
    positive regulation of interleukin-6 production GO:0032755 IEA
    positive regulation of interleukin-6 production GO:0032755 ISO
    interleukin-17A-mediated signaling pathway GO:0038173 IEA
    interleukin-17A-mediated signaling pathway GO:0038173 ISO
    innate immune response GO:0045087 IEA
    positive regulation of inflammatory response GO:0050729 IDA
    positive regulation of inflammatory response GO:0050729 IMP
    positive regulation of inflammatory response GO:0050729 ISO
    defense response to fungus GO:0050832 IMP
    cellular response to cytokine stimulus GO:0071345 ISO
    granulocyte chemotaxis GO:0071621 IMP
    fibroblast activation GO:0072537 IEA
    fibroblast activation GO:0072537 ISO
    T-helper 17 type immune response GO:0072538 IDA
    interleukin-17-mediated signaling pathway GO:0097400 IDA
    interleukin-17-mediated signaling pathway GO:0097400 ISO
    positive regulation of cytokine production involved in inflammatory response GO:1900017 IDA
    positive regulation of cytokine production involved in inflammatory response GO:1900017 IGI
    positive regulation of cytokine production involved in inflammatory response GO:1900017 ISO
    positive regulation of chemokine (C-X-C motif) ligand 1 production GO:2000340 IEA
    positive regulation of chemokine (C-X-C motif) ligand 1 production GO:2000340 ISO
Subcellular Localization
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified Il17ra in sEVs
1
Experiment ID 520
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34112803    
Organism Mus musculus
Experiment description Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution
Authors "Lima LG, Ham S, Shin H, Chai EPZ, Lek ESH, Lobb RJ, Müller AF, Mathivanan S, Yeo B, Choi Y, Parker BS, Möller A. "
Journal name Nat Commun
Publication year 2021
Sample Breast cancer cells
Sample name EO771
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Centrifugal ultrafiltration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 521
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34112803    
Organism Mus musculus
Experiment description Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution
Authors "Lima LG, Ham S, Shin H, Chai EPZ, Lek ESH, Lobb RJ, Müller AF, Mathivanan S, Yeo B, Choi Y, Parker BS, Möller A. "
Journal name Nat Commun
Publication year 2021
Sample Breast cancer cells
Sample name PyMT
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Centrifugal ultrafiltration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for Il17ra
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Il17rc  
Affinity Capture-Western Mus musculus
2 TNFAIP3 7128
Affinity Capture-Western Homo sapiens
3 Traf3ip2  
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
4 Il16  
Co-fractionation Mus musculus
5 Traf6  
Affinity Capture-Western Mus musculus
View the network image/svg+xml
 Pathways in which Il17ra is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here