Gene description for SGMS2
Gene name sphingomyelin synthase 2
Gene symbol SGMS2
Other names/aliases SMS2
Species Homo sapiens
 Database cross references - SGMS2
ExoCarta ExoCarta_166929
Vesiclepedia VP_166929
Entrez Gene 166929
HGNC 28395
MIM 611574
UniProt Q8NHU3  
 SGMS2 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for SGMS2
Molecular Function
    ceramide phosphoethanolamine synthase activity GO:0002950 IEA
    protein binding GO:0005515 IPI
    kinase activity GO:0016301 IEA
    sphingomyelin synthase activity GO:0033188 IBA
    sphingomyelin synthase activity GO:0033188 IDA
    sphingomyelin synthase activity GO:0033188 TAS
    ceramide cholinephosphotransferase activity GO:0047493 IBA
    ceramide cholinephosphotransferase activity GO:0047493 IDA
Biological Process
    sphingomyelin biosynthetic process GO:0006686 IBA
    sphingomyelin biosynthetic process GO:0006686 IDA
    sphingolipid biosynthetic process GO:0030148 TAS
    regulation of bone mineralization GO:0030500 IMP
    ceramide biosynthetic process GO:0046513 IBA
    ceramide phosphoethanolamine biosynthetic process GO:1905373 IEA
Subcellular Localization
    Golgi membrane GO:0000139 IBA
    Golgi membrane GO:0000139 IDA
    nucleoplasm GO:0005654 IDA
    endoplasmic reticulum membrane GO:0005789 IBA
    Golgi apparatus GO:0005794 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified SGMS2 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SGMS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 VAMP1 6843
Two-hybrid Homo sapiens
2 Fam60a 56306
Affinity Capture-MS Mus musculus
3 TMPO 7112
Affinity Capture-MS Homo sapiens
4 GPX8 493869
Two-hybrid Homo sapiens
5 CX3CL1  
Affinity Capture-MS Homo sapiens
6 LPAR3  
Two-hybrid Homo sapiens
7 Bcl7c  
Affinity Capture-MS Mus musculus
8 CENPO  
Affinity Capture-MS Homo sapiens
9 AKAP5  
Affinity Capture-MS Homo sapiens
10 ZFPL1 7542
Two-hybrid Homo sapiens
11 Tnks2  
Affinity Capture-MS Mus musculus
12 PTAR1 375743
Synthetic Lethality Homo sapiens
13 KIF2C 11004
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SGMS2 is involved
PathwayEvidenceSource
Metabolism TAS Reactome
Metabolism of lipids TAS Reactome
Sphingolipid de novo biosynthesis TAS Reactome
Sphingolipid metabolism TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here