Gene description for Stmn1
Gene name stathmin 1
Gene symbol Stmn1
Other names/aliases 19k
Lag
Lap18
Op18
P18
P19
Pig
Pp17
Pp18
Pp19
Pr22
Smn
Species Mus musculus
 Database cross references - Stmn1
ExoCarta ExoCarta_16765
Vesiclepedia VP_16765
Entrez Gene 16765
UniProt P54227  
 Stmn1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Stmn1
Molecular Function
    protein binding GO:0005515 IPI
    tubulin binding GO:0015631 IBA
    tubulin binding GO:0015631 ISO
Biological Process
    mitotic cytokinesis GO:0000281 IGI
    microtubule depolymerization GO:0007019 IBA
    microtubule depolymerization GO:0007019 ISO
    microtubule depolymerization GO:0007019 ISO
    mitotic spindle organization GO:0007052 ISO
    axonogenesis GO:0007409 IMP
    response to virus GO:0009615 IEA
    regulation of cell migration GO:0030334 IGI
    regulation of microtubule polymerization or depolymerization GO:0031110 IBA
    regulation of microtubule polymerization or depolymerization GO:0031110 ISO
    negative regulation of microtubule polymerization GO:0031115 IDA
    negative regulation of microtubule polymerization GO:0031115 ISO
    neuron projection development GO:0031175 IBA
    negative regulation of Rho protein signal transduction GO:0035024 IEA
    negative regulation of Rho protein signal transduction GO:0035024 ISO
    hepatocyte growth factor receptor signaling pathway GO:0048012 IEA
    hepatocyte growth factor receptor signaling pathway GO:0048012 ISO
    negative regulation of stress fiber assembly GO:0051497 IEA
    negative regulation of stress fiber assembly GO:0051497 ISO
    establishment of skin barrier GO:0061436 IEA
    establishment of skin barrier GO:0061436 ISO
    negative regulation of thrombin-activated receptor signaling pathway GO:0070495 IEA
    negative regulation of thrombin-activated receptor signaling pathway GO:0070495 ISO
    negative regulation of guanyl-nucleotide exchange factor activity GO:1905098 ISO
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 ISO
    microtubule GO:0005874 IEA
    membrane GO:0016020 IDA
    neuron projection GO:0043005 IBA
 Experiment description of studies that identified Stmn1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Stmn1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Cdkn1b  
Co-fractionation Mus musculus
2 FMR1 2332
Affinity Capture-MS Homo sapiens
3 APOB 338
Affinity Capture-MS Homo sapiens
4 NUDT21 11051
Affinity Capture-MS Homo sapiens
5 TRIO 7204
Affinity Capture-MS Homo sapiens
6 Ubqln4  
Co-fractionation Mus musculus
7 VCP 7415
Affinity Capture-MS Homo sapiens
8 ERI3 79033
Affinity Capture-MS Homo sapiens
9 FXR1 8087
Affinity Capture-MS Homo sapiens
10 UPP1 7378
Affinity Capture-MS Homo sapiens
11 Kcnma1  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Stmn1 is involved
No pathways found





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