Gene description for Parvb
Gene name parvin, beta
Gene symbol Parvb
Other names/aliases AI595373
AW742462
D15Gsk1
affixin
Species Mus musculus
 Database cross references - Parvb
ExoCarta ExoCarta_170736
Vesiclepedia VP_170736
Entrez Gene 170736
UniProt Q9ES46  
 Parvb identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Parvb
Molecular Function
    actin binding GO:0003779 IBA
    actin binding GO:0003779 IEA
    protein binding GO:0005515 IPI
Biological Process
    cell adhesion GO:0007155 IEA
    cell projection assembly GO:0030031 ISO
    cell projection assembly GO:0030031 ISS
    lamellipodium assembly GO:0030032 IBA
    lamellipodium assembly GO:0030032 ISO
    lamellipodium assembly GO:0030032 ISS
    actin cytoskeleton organization GO:0030036 IBA
    actin cytoskeleton organization GO:0030036 ISO
    actin cytoskeleton organization GO:0030036 ISS
    substrate adhesion-dependent cell spreading GO:0034446 IBA
    establishment or maintenance of cell polarity regulating cell shape GO:0071963 IBA
    establishment or maintenance of cell polarity regulating cell shape GO:0071963 ISO
    establishment or maintenance of cell polarity regulating cell shape GO:0071963 ISS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 IEA
    focal adhesion GO:0005925 IBA
    focal adhesion GO:0005925 ISO
    focal adhesion GO:0005925 ISS
    actin cytoskeleton GO:0015629 IBA
    actin cytoskeleton GO:0015629 IEA
    actin cytoskeleton GO:0015629 ISO
    Z disc GO:0030018 IEA
    lamellipodium GO:0030027 IBA
    lamellipodium GO:0030027 ISO
    lamellipodium GO:0030027 ISS
 Experiment description of studies that identified Parvb in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Parvb
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ilk 16202
Co-fractionation Mus musculus
View the network image/svg+xml



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