Gene description for Rbmxl1
Gene name RNA binding motif protein, X linked-like-1
Gene symbol Rbmxl1
Other names/aliases Hnrpg
Rbmx
Rbmxrt
Species Mus musculus
 Database cross references - Rbmxl1
ExoCarta ExoCarta_19656
Vesiclepedia VP_19656
Entrez Gene 19656
UniProt Q91VM5  
 Rbmxl1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Rbmxl1
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    chromatin binding GO:0003682 IDA
    RNA binding GO:0003723 IBA
    RNA binding GO:0003723 ISO
    RNA binding GO:0003723 ISS
    mRNA binding GO:0003729 ISS
    protein binding GO:0005515 IPI
Biological Process
    regulation of alternative mRNA splicing, via spliceosome GO:0000381 ISS
    transcription by RNA polymerase II GO:0006366 ISS
    mRNA processing GO:0006397 IEA
    membrane protein ectodomain proteolysis GO:0006509 ISS
    RNA splicing GO:0008380 IEA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    negative regulation of mRNA splicing, via spliceosome GO:0048025 ISS
    positive regulation of mRNA splicing, via spliceosome GO:0048026 IBA
    positive regulation of mRNA splicing, via spliceosome GO:0048026 ISS
    protein homooligomerization GO:0051260 ISS
    cellular response to interleukin-1 GO:0071347 ISS
Subcellular Localization
    euchromatin GO:0000791 ISS
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISS
    spliceosomal complex GO:0005681 IBA
    supraspliceosomal complex GO:0044530 ISO
    supraspliceosomal complex GO:0044530 ISS
    extracellular exosome GO:0070062 ISS
    catalytic step 2 spliceosome GO:0071013 ISS
 Experiment description of studies that identified Rbmxl1 in sEVs
1
Experiment ID 15
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Rbmxl1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fitm2  
Negative Genetic Mus musculus
2 Zbtb7b  
Affinity Capture-MS Mus musculus
3 Fzr1  
Affinity Capture-MS Mus musculus
4 Eed  
Affinity Capture-MS Mus musculus
5 Prmt1 15469
Affinity Capture-MS Mus musculus
6 Tfe3  
Affinity Capture-MS Mus musculus
7 Mapt  
Affinity Capture-MS Mus musculus
8 Fancd2  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Rbmxl1 is involved
No pathways found





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