Gene description for TAPT1
Gene name transmembrane anterior posterior transformation 1
Gene symbol TAPT1
Other names/aliases CMVFR
Species Homo sapiens
 Database cross references - TAPT1
ExoCarta ExoCarta_202018
Vesiclepedia VP_202018
Entrez Gene 202018
HGNC 26887
MIM 612758
UniProt Q6NXT6  
 TAPT1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TAPT1
Molecular Function
    growth hormone-releasing hormone receptor activity GO:0016520 TAS
Biological Process
    ossification GO:0001503 IEA
    G protein-coupled receptor signaling pathway GO:0007186 IEA
    neural crest cell development GO:0014032 ISS
    cell projection organization GO:0030030 IEA
    positive regulation of cilium assembly GO:0045724 IBA
    positive regulation of cilium assembly GO:0045724 IDA
    embryonic skeletal system development GO:0048706 IEA
    cartilage development GO:0051216 IEA
    positive regulation of cartilage development GO:0061036 ISS
    positive regulation of bone development GO:1903012 ISS
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    endoplasmic reticulum membrane GO:0005789 IBA
    centrosome GO:0005813 IDA
    cytosol GO:0005829 IDA
    membrane GO:0016020 TAS
    ciliary basal body GO:0036064 IBA
    ciliary basal body GO:0036064 IDA
 Experiment description of studies that identified TAPT1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TAPT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SUCO  
Affinity Capture-MS Homo sapiens
2 KCNS3 3790
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 ZBTB2 57621
Affinity Capture-MS Homo sapiens
4 RIC3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 RPN2 6185
Proximity Label-MS Homo sapiens
6 TXNDC15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 LRRC59 55379
Proximity Label-MS Homo sapiens
8 SEMA7A  
Affinity Capture-MS Homo sapiens
9 KIAA1715 80856
Proximity Label-MS Homo sapiens
10 SEC63 11231
Proximity Label-MS Homo sapiens
11 EMD 2010
Proximity Label-MS Homo sapiens
12 DNAJC25 548645
Proximity Label-MS Homo sapiens
13 PBXIP1 57326
Affinity Capture-MS Homo sapiens
14 SEC62 7095
Proximity Label-MS Homo sapiens
15 ATP2A1 487
Proximity Label-MS Homo sapiens
16 RAB7A 7879
Proximity Label-MS Homo sapiens
17 RAB9A 9367
Proximity Label-MS Homo sapiens
18 DNAJC1 64215
Proximity Label-MS Homo sapiens
19 RPN1 6184
Proximity Label-MS Homo sapiens
20 CKAP4 10970
Proximity Label-MS Homo sapiens
21 ELOVL5 60481
Proximity Label-MS Homo sapiens
22 C1orf95  
Affinity Capture-MS Homo sapiens
23 SEC61B 10952
Proximity Label-MS Homo sapiens
24 DNAJC16  
Proximity Label-MS Homo sapiens
25 DERL1 79139
Proximity Label-MS Homo sapiens
26 PTAR1 375743
Synthetic Lethality Homo sapiens
View the network image/svg+xml
 Pathways in which TAPT1 is involved
No pathways found





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