Gene description for DHRSX
Gene name dehydrogenase/reductase (SDR family) X-linked
Gene symbol DHRSX
Other names/aliases CXorf11
DHRS5X
DHRS5Y
DHRSXY
DHRSY
SDR46C1
SDR7C6
Species Homo sapiens
 Database cross references - DHRSX
ExoCarta ExoCarta_207063
Vesiclepedia VP_207063
Entrez Gene 207063
HGNC 18399
UniProt Q8N5I4  
 DHRSX identified in sEVs derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for DHRSX
Molecular Function
    protein binding GO:0005515 IPI
    polyprenol dehydrogenase activity GO:0160196 IDA
    dolichal reductase activity GO:0160197 IDA
Biological Process
    positive regulation of autophagy GO:0010508 IBA
    positive regulation of autophagy GO:0010508 IMP
    dolichol biosynthetic process GO:0019408 IDA
Subcellular Localization
    extracellular region GO:0005576 IBA
    extracellular region GO:0005576 IDA
    lipid droplet GO:0005811 IDA
 Experiment description of studies that identified DHRSX in sEVs
1
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for DHRSX
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Reconstituted Complex Homo sapiens
2 TMEM31  
Two-hybrid Homo sapiens
3 GCNT3 9245
Two-hybrid Homo sapiens
4 ATXN1 6310
Two-hybrid Homo sapiens
5 APOC1  
Two-hybrid Homo sapiens
6 TMEM86B  
Two-hybrid Homo sapiens
7 TMEM56  
Two-hybrid Homo sapiens
8 TMEM14B  
Two-hybrid Homo sapiens
9 CIDEB  
Two-hybrid Homo sapiens
10 FAM134C 162427
Two-hybrid Homo sapiens
11 HSD17B11 51170
Two-hybrid Homo sapiens
12 C16orf58 64755
Two-hybrid Homo sapiens
13 TMEM143  
Two-hybrid Homo sapiens
14 PGRMC2 10424
Two-hybrid Homo sapiens
15 ZDHHC15 158866
Two-hybrid Homo sapiens
16 CMTM5  
Two-hybrid Homo sapiens
17 FADS3 3995
Two-hybrid Homo sapiens
18 ASPH 444
Two-hybrid Homo sapiens
19 ZBED1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 PIGP  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which DHRSX is involved
No pathways found





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