Gene description for F7
Gene name coagulation factor VII (serum prothrombin conversion accelerator)
Gene symbol F7
Other names/aliases SPCA
Species Homo sapiens
 Database cross references - F7
ExoCarta ExoCarta_2155
Vesiclepedia VP_2155
Entrez Gene 2155
HGNC 3544
MIM 613878
UniProt P08709  
 F7 identified in sEVs derived from the following tissue/cell type
Colorectal cancer cells 19837982    
 Gene ontology annotations for F7
Molecular Function
    serine-type endopeptidase activity GO:0004252 IDA
    signaling receptor binding GO:0005102 IEA
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    serine-type peptidase activity GO:0008236 TAS
Biological Process
    response to hypoxia GO:0001666 IEA
    positive regulation of leukocyte chemotaxis GO:0002690 IBA
    positive regulation of leukocyte chemotaxis GO:0002690 IDA
    blood coagulation GO:0007596 IBA
    blood coagulation GO:0007596 IDA
    circadian rhythm GO:0007623 IEA
    response to carbon dioxide GO:0010037 IEA
    positive regulation of platelet-derived growth factor receptor signaling pathway GO:0010641 IDA
    protein processing GO:0016485 IDA
    positive regulation of blood coagulation GO:0030194 IEA
    positive regulation of cell migration GO:0030335 TAS
    animal organ regeneration GO:0031100 IEA
    positive regulation of TOR signaling GO:0032008 IDA
    response to estradiol GO:0032355 IEA
    response to vitamin K GO:0032571 IEA
    response to genistein GO:0033595 IEA
    response to estrogen GO:0043627 IEA
    positive regulation of positive chemotaxis GO:0050927 IDA
    response to growth hormone GO:0060416 IEA
    response to cholesterol GO:0070723 IEA
    response to thyroxine GO:0097068 IEA
    response to Thyroid stimulating hormone GO:1904400 IEA
    response to 2,3,7,8-tetrachlorodibenzodioxine GO:1904612 IEA
    response to astaxanthin GO:1905217 IEA
    response to thyrotropin-releasing hormone GO:1905225 IEA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    endoplasmic reticulum lumen GO:0005788 TAS
    Golgi lumen GO:0005796 TAS
    plasma membrane GO:0005886 TAS
    vesicle GO:0031982 IEA
    collagen-containing extracellular matrix GO:0062023 HDA
    serine-type peptidase complex GO:1905286 IPI
 Experiment description of studies that identified F7 in sEVs
1
Experiment ID 21
MISEV standards
EM|IEM
Biophysical techniques
Alix|TSG101|HSP70|CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method
Mass spectrometry   
PubMed ID 19837982    
Organism Homo sapiens
Experiment description Proteomic and bioinformatic analysis of immunoaffinity-purified exosomes derived from the human colon tumor cell line LIM1215.
Authors "Suresh Mathivanan, Justin W.E. Lim, Bow J. Tauro, Hong Ji, Robert L. Moritz and Richard J. Simpson"
Journal name MCP
Publication year 2009
Sample Colorectal cancer cells
Sample name LIM1215
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.10-1.12 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for F7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 F10 2159
Biochemical Activity Homo sapiens
2 NMU  
Affinity Capture-MS Homo sapiens
3 CRELD2 79174
Affinity Capture-MS Homo sapiens
4 ALB 213
Affinity Capture-MS Homo sapiens
5 CEP250 11190
Affinity Capture-MS Homo sapiens
6 C1QL1  
Affinity Capture-MS Homo sapiens
7 CEP76  
Affinity Capture-MS Homo sapiens
8 DMWD  
Affinity Capture-MS Homo sapiens
9 USP49 25862
Affinity Capture-MS Homo sapiens
10 F3 2152
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
11 RCHY1  
Two-hybrid Homo sapiens
12 UIMC1  
Affinity Capture-MS Homo sapiens
13 FUS 2521
Affinity Capture-MS Homo sapiens
14 USP7 7874
Affinity Capture-MS Homo sapiens
15 VCP 7415
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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