Gene description for Rab3ip
Gene name RAB3A interacting protein
Gene symbol Rab3ip
Other names/aliases B230311A06
Gtpat12
Rabin3
Species Mus musculus
 Database cross references - Rab3ip
ExoCarta ExoCarta_216363
Vesiclepedia VP_216363
Entrez Gene 216363
UniProt Q68EF0  
 Rab3ip identified in sEVs derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Rab3ip
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 IBA
    guanyl-nucleotide exchange factor activity GO:0005085 ISO
    guanyl-nucleotide exchange factor activity GO:0005085 ISS
    protein binding GO:0005515 IPI
    small GTPase binding GO:0031267 IDA
    small GTPase binding GO:0031267 IMP
    identical protein binding GO:0042802 IDA
    identical protein binding GO:0042802 ISO
    GTPase binding GO:0051020 ISO
Biological Process
    protein targeting to membrane GO:0006612 ISO
    protein transport GO:0015031 IEA
    protein localization to organelle GO:0033365 ISO
    positive regulation of cilium assembly GO:0045724 ISO
    negative regulation of filopodium assembly GO:0051490 ISO
    cilium assembly GO:0060271 ISO
    protein localization to motile cilium GO:0120229 ISO
Subcellular Localization
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 ISO
    centrosome GO:0005813 IEA
    centrosome GO:0005813 ISO
    cytosol GO:0005829 IBA
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISS
    lamellipodium GO:0030027 IEA
    vesicle GO:0031982 IEA
    perinuclear region of cytoplasm GO:0048471 ISO
    proximal dendrite GO:1990635 ISO
 Experiment description of studies that identified Rab3ip in sEVs
1
Experiment ID 264
MISEV standards
Biophysical techniques
CD63|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-? via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors "Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino"
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th2 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Rab3ip
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Hcn1  
Affinity Capture-MS Mus musculus
2 Ppl  
Co-fractionation Mus musculus
3 Ywhae 22627
Affinity Capture-MS Mus musculus
View the network image/svg+xml



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