Gene description for Tnfrsf1a
Gene name	tumor necrosis factor receptor superfamily, member 1a
Gene symbol	Tnfrsf1a
Other names/aliases	CD120a FPF TNF-R TNF-R-I TNF-R1 TNF-R55 TNF-alphaR1 TNFAR TNFR60 TNFRI TNFRp55 TNFalpha-R1 Tnfr-2 Tnfr1 p55 p55-R
Species	Mus musculus
Database cross references - Tnfrsf1a
ExoCarta	ExoCarta_21937
Vesiclepedia	VP_21937
Entrez Gene	21937
UniProt	P25118
Tnfrsf1a identified in sEVs derived from the following tissue/cell type
Breast cancer cells	34112803
Breast cancer cells	34112803
Neural stem cells	25242146

Gene ontology annotations for Tnfrsf1a

Molecular Function     protease binding GO:0002020 ISO     tumor necrosis factor receptor activity GO:0005031 IBA     tumor necrosis factor receptor activity GO:0005031 IDA     tumor necrosis factor receptor activity GO:0005031 IGI     tumor necrosis factor receptor activity GO:0005031 IMP     tumor necrosis factor receptor activity GO:0005031 IPI     tumor necrosis factor receptor activity GO:0005031 ISO     tumor necrosis factor receptor activity GO:0005031 TAS     protein binding GO:0005515 IPI     signaling receptor activity GO:0038023 IDA     tumor necrosis factor binding GO:0043120 IBA     tumor necrosis factor binding GO:0043120 IEA     tumor necrosis factor binding GO:0043120 ISO     protein-containing complex binding GO:0044877 ISO Biological Process     aortic valve development GO:0003176 IGI     pulmonary valve development GO:0003177 IGI     negative regulation of extracellular matrix constituent secretion GO:0003332 IGI     transcription by RNA polymerase II GO:0006366 IMP     prostaglandin metabolic process GO:0006693 TAS     defense response GO:0006952 IMP     inflammatory response GO:0006954 IBA     inflammatory response GO:0006954 IMP     cell surface receptor signaling pathway GO:0007166 IMP     cell surface receptor signaling pathway via JAK-STAT GO:0007259 IEA     extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 TAS     intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 IMP     negative regulation of cardiac muscle hypertrophy GO:0010614 IGI     positive regulation of gene expression GO:0010628 ISO     negative regulation of gene expression GO:0010629 ISO     regulation of tumor necrosis factor-mediated signaling pathway GO:0010803 IGI     cytokine-mediated signaling pathway GO:0019221 IMP     negative regulation of interleukin-6 production GO:0032715 ISO     positive regulation of tumor necrosis factor production GO:0032760 ISO     tumor necrosis factor-mediated signaling pathway GO:0033209 IGI     tumor necrosis factor-mediated signaling pathway GO:0033209 ISO     tumor necrosis factor-mediated signaling pathway GO:0033209 TAS     positive regulation of amide metabolic process GO:0034250 IGI     positive regulation of protein import into nucleus GO:0042307 ISO     positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 ISO     defense response to bacterium GO:0042742 IMP     regulation of apoptotic process GO:0042981 ISO     negative regulation of apoptotic process GO:0043066 ISO     positive regulation of canonical NF-kappaB signal transduction GO:0043123 IMP     positive regulation of neuron apoptotic process GO:0043525 ISO     positive regulation of angiogenesis GO:0045766 ISO     positive regulation of lipid metabolic process GO:0045834 IGI     positive regulation of transcription by RNA polymerase II GO:0045944 IMP     positive regulation of transcription by RNA polymerase II GO:0045944 ISO     negative regulation of inflammatory response GO:0050728 IEA     negative regulation of inflammatory response GO:0050728 ISO     positive regulation of inflammatory response GO:0050729 IMP     cellular response to mechanical stimulus GO:0071260 IEA     protein localization to plasma membrane GO:0072659 IEA     protein localization to plasma membrane GO:0072659 ISO     positive regulation of execution phase of apoptosis GO:1900119 IGI     positive regulation of execution phase of apoptosis GO:1900119 IMP     positive regulation of apoptotic process involved in morphogenesis GO:1902339 IGI     regulation of establishment of endothelial barrier GO:1903140 IEA     regulation of establishment of endothelial barrier GO:1903140 ISO     regulation of membrane lipid metabolic process GO:1905038 IGI Subcellular Localization     Golgi membrane GO:0000139 ISO     Golgi membrane GO:0000139 ISS     extracellular space GO:0005615 IEA     extracellular space GO:0005615 ISO     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 TAS     cell surface GO:0009986 IDA     cell surface GO:0009986 ISO     cell surface GO:0009986 ISO     axon GO:0030424 ISO     protein-containing complex GO:0032991 ISO     receptor complex GO:0043235 IBA     receptor complex GO:0043235 ISO     membrane raft GO:0045121 IBA     membrane raft GO:0045121 IDA     membrane raft GO:0045121 ISO