Gene description for REEP3
Gene name receptor accessory protein 3
Gene symbol REEP3
Other names/aliases C10orf74
Species Homo sapiens
 Database cross references - REEP3
ExoCarta ExoCarta_221035
Vesiclepedia VP_221035
Entrez Gene 221035
HGNC 23711
MIM 609348
UniProt Q6NUK4  
 REEP3 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for REEP3
Molecular Function
    protein binding GO:0005515 IPI
    microtubule binding GO:0008017 IBA
Biological Process
    nuclear envelope organization GO:0006998 IMP
    mitotic nuclear membrane reassembly GO:0007084 IMP
    cell division GO:0051301 IEA
    endoplasmic reticulum tubular network organization GO:0071786 IBA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IBA
    cytoplasmic microtubule GO:0005881 IBA
    endoplasmic reticulum tubular network GO:0071782 IBA
 Experiment description of studies that identified REEP3 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for REEP3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAH 7533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 LRFN1  
Affinity Capture-MS Homo sapiens
3 FNDC4 64838
Affinity Capture-MS Homo sapiens
4 UBE2O 63893
Affinity Capture-MS Homo sapiens
5 RAB3GAP2 25782
Affinity Capture-MS Homo sapiens
6 KSR1  
Affinity Capture-MS Homo sapiens
7 YEATS4  
Affinity Capture-MS Homo sapiens
8 YWHAB 7529
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 YWHAE 7531
Affinity Capture-MS Homo sapiens
10 YWHAZ 7534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 MRPL50 54534
Affinity Capture-MS Homo sapiens
12 REEP4  
Affinity Capture-MS Homo sapiens
13 CBY1  
Affinity Capture-MS Homo sapiens
14 SAMD1  
Affinity Capture-MS Homo sapiens
15 BAG6 7917
Affinity Capture-MS Homo sapiens
16 KIF13B 23303
Affinity Capture-MS Homo sapiens
17 REEP2  
Affinity Capture-MS Homo sapiens
18 REEP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 ZBTB21  
Affinity Capture-MS Homo sapiens
20 GIGYF1  
Affinity Capture-MS Homo sapiens
21 YWHAQ 10971
Affinity Capture-MS Homo sapiens
22 RAB3GAP1 22930
Affinity Capture-MS Homo sapiens
23 Rpl35 66489
Affinity Capture-MS Mus musculus
24 YWHAG 7532
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 KCTD3  
Affinity Capture-MS Homo sapiens
26 C3orf52  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which REEP3 is involved
No pathways found





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