Gene description for NAPEPLD
Gene name N-acyl phosphatidylethanolamine phospholipase D
Gene symbol NAPEPLD
Other names/aliases FMP30
NAPE-PLD
Species Homo sapiens
 Database cross references - NAPEPLD
ExoCarta ExoCarta_222236
Vesiclepedia VP_222236
Entrez Gene 222236
HGNC 21683
MIM 612334
UniProt Q6IQ20  
 NAPEPLD identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for NAPEPLD
Molecular Function
    zinc ion binding GO:0008270 IDA
    bile acid binding GO:0032052 IDA
    identical protein binding GO:0042802 IPI
    N-acylphosphatidylethanolamine-specific phospholipase D activity GO:0070290 IBA
    N-acylphosphatidylethanolamine-specific phospholipase D activity GO:0070290 IDA
    N-acylphosphatidylethanolamine-specific phospholipase D activity GO:0070290 TAS
Biological Process
    retinoid metabolic process GO:0001523 TAS
    temperature homeostasis GO:0001659 ISS
    phospholipid catabolic process GO:0009395 IEA
    host-mediated regulation of intestinal microbiota composition GO:0048874 ISS
    positive regulation of inflammatory response GO:0050729 ISS
    N-acylethanolamine metabolic process GO:0070291 IBA
    N-acylphosphatidylethanolamine metabolic process GO:0070292 IBA
    N-acylphosphatidylethanolamine metabolic process GO:0070292 IDA
    positive regulation of brown fat cell differentiation GO:0090336 ISS
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    nuclear envelope GO:0005635 ISS
    nucleoplasm GO:0005654 ISS
    cytoplasm GO:0005737 IBA
    early endosome GO:0005769 ISS
    Golgi apparatus GO:0005794 IDA
    smooth endoplasmic reticulum membrane GO:0030868 IEA
    early endosome membrane GO:0031901 IEA
    photoreceptor outer segment membrane GO:0042622 TAS
    presynaptic membrane GO:0042734 IEA
    membrane-bounded organelle GO:0043227 IBA
    postsynaptic membrane GO:0045211 IEA
    extracellular exosome GO:0070062 HDA
    hippocampal mossy fiber to CA3 synapse GO:0098686 IEA
 Experiment description of studies that identified NAPEPLD in sEVs
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for NAPEPLD
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CLEC4M  
Affinity Capture-MS Homo sapiens
2 PPP1CC 5501
Two-hybrid Homo sapiens
View the network image/svg+xml



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