Gene description for GPC5
Gene name glypican 5
Gene symbol GPC5
Other names/aliases -
Species Homo sapiens
 Database cross references - GPC5
ExoCarta ExoCarta_2262
Vesiclepedia VP_2262
Entrez Gene 2262
HGNC 4453
MIM 602446
UniProt P78333  
 GPC5 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for GPC5
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    cell migration GO:0016477 IBA
    positive regulation of canonical Wnt signaling pathway GO:0090263 IBA
    regulation of protein localization to membrane GO:1905475 IBA
Subcellular Localization
    extracellular region GO:0005576 TAS
    Golgi lumen GO:0005796 TAS
    plasma membrane GO:0005886 TAS
    cell surface GO:0009986 IBA
    membrane GO:0016020 TAS
    lysosomal lumen GO:0043202 TAS
    collagen-containing extracellular matrix GO:0062023 IEA
    side of membrane GO:0098552 IEA
 Experiment description of studies that identified GPC5 in sEVs
1
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for GPC5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 POU2F1 5451
Affinity Capture-MS Homo sapiens
2 SPCS2 9789
Affinity Capture-MS Homo sapiens
3 Shcbp1 20419
Affinity Capture-MS Mus musculus
4 HSPG2 3339
Affinity Capture-MS Homo sapiens
5 HSPA5 3309
Affinity Capture-MS Homo sapiens
6 PPP2R2D 55844
Affinity Capture-MS Homo sapiens
7 FXYD6  
Affinity Capture-MS Homo sapiens
8 DCPS 28960
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which GPC5 is involved
PathwayEvidenceSource
A tetrasaccharide linker sequence is required for GAG synthesis TAS Reactome
Attachment and Entry TAS Reactome
Attachment and Entry IEA Reactome
Chondroitin sulfate/dermatan sulfate metabolism TAS Reactome
Defective B3GALT6 causes EDSP2 and SEMDJL1 TAS Reactome
Defective B3GAT3 causes JDSSDHD TAS Reactome
Defective B4GALT7 causes EDS, progeroid type TAS Reactome
Defective EXT1 causes exostoses 1, TRPS2 and CHDS TAS Reactome
Defective EXT2 causes exostoses 2 TAS Reactome
Disease TAS Reactome
Disease IEA Reactome
Diseases associated with glycosaminoglycan metabolism TAS Reactome
Diseases of glycosylation TAS Reactome
Diseases of metabolism TAS Reactome
Early SARS-CoV-2 Infection Events TAS Reactome
Early SARS-CoV-2 Infection Events IEA Reactome
Glycosaminoglycan metabolism TAS Reactome
Glycosaminoglycan metabolism IEA Reactome
Hedgehog ligand biogenesis TAS Reactome
Heparan sulfate/heparin (HS-GAG) metabolism TAS Reactome
Heparan sulfate/heparin (HS-GAG) metabolism IEA Reactome
HS-GAG biosynthesis TAS Reactome
HS-GAG biosynthesis IEA Reactome
HS-GAG degradation TAS Reactome
Infectious disease TAS Reactome
Infectious disease IEA Reactome
Metabolism TAS Reactome
Metabolism IEA Reactome
Metabolism of carbohydrates TAS Reactome
Metabolism of carbohydrates IEA Reactome
Metabolism of fat-soluble vitamins TAS Reactome
Metabolism of vitamins and cofactors TAS Reactome
Release of Hh-Np from the secreting cell TAS Reactome
Respiratory syncytial virus (RSV) attachment and entry TAS Reactome
Respiratory Syncytial Virus Infection Pathway TAS Reactome
Retinoid metabolism and transport TAS Reactome
RSV-host interactions TAS Reactome
SARS-CoV Infections TAS Reactome
SARS-CoV Infections IEA Reactome
SARS-CoV-2 Infection TAS Reactome
SARS-CoV-2 Infection IEA Reactome
Sensory Perception TAS Reactome
Signal Transduction TAS Reactome
Signaling by Hedgehog TAS Reactome
Viral Infection Pathways TAS Reactome
Viral Infection Pathways IEA Reactome
Visual phototransduction TAS Reactome





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