Gene description for Gmps
Gene name guanine monophosphate synthetase
Gene symbol Gmps
Other names/aliases AA591640
AI047208
Species Mus musculus
 Database cross references - Gmps
ExoCarta ExoCarta_229363
Vesiclepedia VP_229363
Entrez Gene 229363
UniProt Q3THK7  
 Gmps identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Gmps
Molecular Function
    GMP synthase activity GO:0003921 IBA
    GMP synthase activity GO:0003921 ISO
    GMP synthase (glutamine-hydrolyzing) activity GO:0003922 IDA
    GMP synthase (glutamine-hydrolyzing) activity GO:0003922 ISO
    ATP binding GO:0005524 IEA
    enzyme binding GO:0019899 ISO
Biological Process
    GMP biosynthetic process GO:0006177 IBA
    GMP biosynthetic process GO:0006177 IDA
    GMP biosynthetic process GO:0006177 ISO
    GMP biosynthetic process GO:0006177 ISO
    GMP salvage GO:0032263 ISO
    response to L-cysteine GO:1901367 ISO
Subcellular Localization
    cytosol GO:0005829 IBA
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISS
 Experiment description of studies that identified Gmps in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Gmps
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Psmd5 66998
Co-fractionation Mus musculus
2 Atxn1  
Proximity Label-MS Mus musculus
Affinity Capture-MS Mus musculus
3 Foxp3  
Affinity Capture-MS Mus musculus
4 Eed  
Affinity Capture-MS Mus musculus
5 Atg12  
Negative Genetic Mus musculus
6 Rcn1  
Co-fractionation Mus musculus
7 Fancd2  
Affinity Capture-MS Mus musculus
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