Gene description for Ssh1
Gene name slingshot homolog 1 (Drosophila)
Gene symbol Ssh1
Other names/aliases AW551225
Gm1394
Gm1395
SSH-1
mSSH-1L
Species Mus musculus
 Database cross references - Ssh1
ExoCarta ExoCarta_231637
Vesiclepedia VP_231637
Entrez Gene 231637
UniProt Q76I79  
 Ssh1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ssh1
Molecular Function
    actin binding GO:0003779 IBA
    actin binding GO:0003779 IEA
    actin binding GO:0003779 ISO
    phosphoprotein phosphatase activity GO:0004721 IBA
    phosphoprotein phosphatase activity GO:0004721 ISO
    non-membrane spanning protein tyrosine phosphatase activity GO:0004726 IEA
    myosin phosphatase activity GO:0017018 IEA
    protein tyrosine phosphatase activity, metal-dependent GO:0030946 IEA
    calmodulin-dependent protein phosphatase activity GO:0033192 IEA
    histone H2AXS140 phosphatase activity GO:0140791 IEA
    histone H2AXY142 phosphatase activity GO:0140793 IEA
    RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity GO:0180004 IEA
    RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity GO:0180005 IEA
    RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity GO:0180006 IEA
    RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity GO:0180007 IEA
    RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity GO:0180008 IEA
    MAP kinase serine/threonine phosphatase activity GO:1990439 IEA
Biological Process
    cell morphogenesis GO:0000902 IEA
    cell morphogenesis GO:0000902 ISO
    chromatin remodeling GO:0006338 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IEA
    protein dephosphorylation GO:0006470 ISO
    actin cytoskeleton organization GO:0030036 IBA
    actin cytoskeleton organization GO:0030036 IEA
    actin cytoskeleton organization GO:0030036 ISO
    negative regulation of actin filament polymerization GO:0030837 IBA
    negative regulation of actin filament polymerization GO:0030837 IEA
    positive regulation of synaptic plasticity GO:0031915 IEA
    positive regulation of synaptic plasticity GO:0031915 ISO
    regulation of protein metabolic process GO:0051246 ISO
    cellular response to ATP GO:0071318 ISO
    excitatory chemical synaptic transmission GO:0098976 IEA
    excitatory chemical synaptic transmission GO:0098976 ISO
    positive regulation of AMPA glutamate receptor clustering GO:1904719 IEA
    positive regulation of AMPA glutamate receptor clustering GO:1904719 ISO
    positive regulation of vascular associated smooth muscle cell migration GO:1904754 IEA
    positive regulation of vascular associated smooth muscle cell migration GO:1904754 ISO
    positive regulation of excitatory postsynaptic potential GO:2000463 IEA
    positive regulation of excitatory postsynaptic potential GO:2000463 ISO
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IEA
    cytoplasm GO:0005737 ISO
    cytoskeleton GO:0005856 IEA
    plasma membrane GO:0005886 ISO
    growth cone GO:0030426 IEA
    growth cone GO:0030426 ISO
    midbody GO:0030496 IEA
    cell leading edge GO:0031252 IEA
    cell leading edge GO:0031252 ISO
    cleavage furrow GO:0032154 IEA
    cell projection GO:0042995 ISO
    synapse GO:0045202 IEA
 Experiment description of studies that identified Ssh1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ssh1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fancd2  
Affinity Capture-MS Mus musculus
2 Mycbp2 105689
Affinity Capture-MS Mus musculus
3 Limk1  
Co-fractionation Mus musculus
4 Champ1  
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Ssh1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here