Gene description for SGK3
Gene name serum/glucocorticoid regulated kinase family, member 3
Gene symbol SGK3
Other names/aliases CISK
SGK2
SGKL
Species Homo sapiens
 Database cross references - SGK3
ExoCarta ExoCarta_23678
Vesiclepedia VP_23678
Entrez Gene 23678
HGNC 10812
MIM 607591
UniProt Q96BR1  
 SGK3 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for SGK3
Molecular Function
    protein kinase activity GO:0004672 TAS
    protein serine/threonine kinase activity GO:0004674 IBA
    3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA
    DNA-dependent protein kinase activity GO:0004677 IEA
    AMP-activated protein kinase activity GO:0004679 IEA
    eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA
    ribosomal protein S6 kinase activity GO:0004711 IEA
    calcium channel regulator activity GO:0005246 TAS
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    potassium channel regulator activity GO:0015459 IBA
    potassium channel regulator activity GO:0015459 TAS
    sodium channel regulator activity GO:0017080 TAS
    chloride channel regulator activity GO:0017081 TAS
    phosphatidylinositol binding GO:0035091 IEA
    histone H3S10 kinase activity GO:0035175 IEA
    histone H3T11 kinase activity GO:0035402 IEA
    histone H3T6 kinase activity GO:0035403 IEA
    histone H2AXS139 kinase activity GO:0035979 IEA
    histone H3S28 kinase activity GO:0044022 IEA
    histone H4S1 kinase activity GO:0044023 IEA
    histone H2AS1 kinase activity GO:0044024 IEA
    histone H2BS14 kinase activity GO:0044025 IEA
    histone H3T3 kinase activity GO:0072354 IEA
    histone H2AS121 kinase activity GO:0072371 IEA
    Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA
    protein serine kinase activity GO:0106310 IEA
    histone H2BS36 kinase activity GO:0140823 IEA
    histone H3S57 kinase activity GO:0140855 IEA
    histone H3T45 kinase activity GO:0140857 IEA
    histone H2AT120 kinase activity GO:1990244 IEA
Biological Process
    regulation of cell growth GO:0001558 TAS
    chromatin remodeling GO:0006338 IEA
    protein phosphorylation GO:0006468 TAS
    regulation of cell migration GO:0030334 TAS
    intracellular signal transduction GO:0035556 IBA
    regulation of cell population proliferation GO:0042127 TAS
    regulation of DNA-binding transcription factor activity GO:0051090 TAS
    negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 IEA
Subcellular Localization
    early endosome GO:0005769 IEA
    cytosol GO:0005829 TAS
    recycling endosome GO:0055037 IEA
 Experiment description of studies that identified SGK3 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SGK3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CYP19A1  
Affinity Capture-MS Homo sapiens
2 APP 351
Reconstituted Complex Homo sapiens
3 DNLZ  
Affinity Capture-MS Homo sapiens
4 ESR1  
Affinity Capture-RNA Homo sapiens
5 AMHR2  
Affinity Capture-MS Homo sapiens
6 CDC37 11140
Affinity Capture-MS Homo sapiens
7 GSK3B 2932
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
8 HSP90AA4P 3323
Affinity Capture-MS Homo sapiens
9 ITCH 83737
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
10 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
11 ICAM1 3383
Affinity Capture-MS Homo sapiens
12 CTNNBIP1 56998
Affinity Capture-MS Homo sapiens
13 CD79B 974
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SGK3 is involved
PathwayEvidenceSource
Ion channel transport TAS Reactome
Stimuli-sensing channels TAS Reactome
Transport of small molecules TAS Reactome





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