Gene description for Erc2
Gene name ELKS/RAB6-interacting/CAST family member 2
Gene symbol Erc2
Other names/aliases 6430531D06
CAST
CAST1/ERC2
D14Ertd171e
ELKS2alpha
Species Mus musculus
 Database cross references - Erc2
ExoCarta ExoCarta_238988
Vesiclepedia VP_238988
Entrez Gene 238988
UniProt Q6PH08  
 Erc2 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Erc2
Molecular Function
    protein binding GO:0005515 IPI
    PDZ domain binding GO:0030165 ISO
    protein-containing complex binding GO:0044877 ISO
    structural constituent of presynaptic active zone GO:0098882 IBA
    structural constituent of presynaptic active zone GO:0098882 IDA
    structural constituent of presynaptic active zone GO:0098882 IEP
    structural constituent of presynaptic active zone GO:0098882 IMP
Biological Process
    synaptic vesicle priming GO:0016082 IDA
    synaptic vesicle priming GO:0016082 IMP
    maintenance of presynaptic active zone structure GO:0048790 IBA
    maintenance of presynaptic active zone structure GO:0048790 IEA
    regulation of presynaptic cytosolic calcium ion concentration GO:0099509 IDA
    regulation of presynaptic cytosolic calcium ion concentration GO:0099509 IMP
    regulation of calcium-dependent activation of synaptic vesicle fusion GO:0150037 IDA
    regulation of calcium-dependent activation of synaptic vesicle fusion GO:0150037 IMP
Subcellular Localization
    Golgi-associated vesicle GO:0005798 ISO
    cytoskeleton GO:0005856 IEA
    growth cone GO:0030426 ISO
    growth cone GO:0030426 ISS
    protein-containing complex GO:0032991 ISO
    presynaptic membrane GO:0042734 ISO
    presynaptic membrane GO:0042734 ISS
    neuronal cell body GO:0043025 ISO
    terminal bouton GO:0043195 ISO
    synapse GO:0045202 IDA
    presynaptic active zone GO:0048786 ISO
    presynaptic active zone cytoplasmic component GO:0098831 IBA
    presynaptic active zone cytoplasmic component GO:0098831 IDA
    presynaptic active zone cytoplasmic component GO:0098831 ISO
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IMP
    GABA-ergic synapse GO:0098982 IDA
    GABA-ergic synapse GO:0098982 IMP
 Experiment description of studies that identified Erc2 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Erc2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Lnx1  
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
2 Tnik  
Affinity Capture-MS Mus musculus
3 Cyfip1 20430
Affinity Capture-MS Mus musculus
4 Kctd13  
Affinity Capture-MS Mus musculus
5 Pde4dip  
Affinity Capture-MS Mus musculus
6 Lnx2  
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
7 Shank3  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
8 Ywhae 22627
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Erc2 is involved
No pathways found





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