Gene description for C3
Gene name	complement component 3
Gene symbol	C3
Other names/aliases	-
Species	Rattus norvegicus
Database cross references - C3
ExoCarta	ExoCarta_24232
Vesiclepedia	VP_24232
Entrez Gene	24232
UniProt	P01026
C3 identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for C3

Molecular Function     endopeptidase inhibitor activity GO:0004866 IEA     protein binding GO:0005515 IPI     lipid binding GO:0008289 IDA     C5L2 anaphylatoxin chemotactic receptor binding GO:0031715 IEA     C5L2 anaphylatoxin chemotactic receptor binding GO:0031715 ISO     C5L2 anaphylatoxin chemotactic receptor binding GO:0031715 ISS     receptor ligand activity GO:0048018 IEA     receptor ligand activity GO:0048018 ISO Biological Process     positive regulation of type IIa hypersensitivity GO:0001798 IEA     positive regulation of type IIa hypersensitivity GO:0001798 ISO     positive regulation of protein phosphorylation GO:0001934 ISO     positive regulation of protein phosphorylation GO:0001934 ISS     positive regulation of activation of membrane attack complex GO:0001970 IEA     positive regulation of activation of membrane attack complex GO:0001970 ISO     complement receptor mediated signaling pathway GO:0002430 IEA     complement receptor mediated signaling pathway GO:0002430 ISO     tolerance induction GO:0002507 IEP     fatty acid metabolic process GO:0006631 IEA     chemotaxis GO:0006935 IEA     inflammatory response GO:0006954 IEA     complement activation GO:0006956 IBA     complement activation GO:0006956 IDA     complement activation GO:0006956 ISO     complement activation GO:0006956 ISO     complement activation, alternative pathway GO:0006957 IEA     complement activation, classical pathway GO:0006958 IEA     complement activation, classical pathway GO:0006958 TAS     response to xenobiotic stimulus GO:0009410 IEP     response to bacterium GO:0009617 IEA     response to bacterium GO:0009617 ISO     positive regulation of vascular endothelial growth factor production GO:0010575 IEA     positive regulation of vascular endothelial growth factor production GO:0010575 ISO     positive regulation of D-glucose transmembrane transport GO:0010828 IEA     positive regulation of D-glucose transmembrane transport GO:0010828 ISO     positive regulation of D-glucose transmembrane transport GO:0010828 ISS     regulation of triglyceride biosynthetic process GO:0010866 IEA     regulation of triglyceride biosynthetic process GO:0010866 ISO     regulation of triglyceride biosynthetic process GO:0010866 ISS     positive regulation of lipid storage GO:0010884 IEA     positive regulation of lipid storage GO:0010884 ISO     positive regulation of lipid storage GO:0010884 ISS     neuron remodeling GO:0016322 IEA     neuron remodeling GO:0016322 ISO     response to magnesium ion GO:0032026 IEP     response to estradiol GO:0032355 IEP     response to progesterone GO:0032570 IEP     oviduct epithelium development GO:0035846 IEA     oviduct epithelium development GO:0035846 ISO     vascular associated smooth muscle cell differentiation GO:0035886 ISO     B cell activation GO:0042113 IEA     B cell activation GO:0042113 ISO     response to estrogen GO:0043627 IEP     innate immune response GO:0045087 ISO     positive regulation of G protein-coupled receptor signaling pathway GO:0045745 IEA     positive regulation of G protein-coupled receptor signaling pathway GO:0045745 ISO     positive regulation of G protein-coupled receptor signaling pathway GO:0045745 ISS     positive regulation of angiogenesis GO:0045766 IEA     positive regulation of angiogenesis GO:0045766 ISO     positive regulation of receptor-mediated endocytosis GO:0048260 IEA     positive regulation of receptor-mediated endocytosis GO:0048260 ISO     positive regulation of developmental growth GO:0048639 IDA     positive regulation of phagocytosis GO:0050766 ISO     response to glucocorticoid GO:0051384 IEP     retina development in camera-type eye GO:0060041 ISO     positive regulation of phagocytosis, engulfment GO:0060100 IEA     positive regulation of phagocytosis, engulfment GO:0060100 ISO     positive regulation of ERK1 and ERK2 cascade GO:0070374 IDA     amyloid-beta clearance GO:0097242 IEA     amyloid-beta clearance GO:0097242 ISO     complement-dependent cytotoxicity GO:0097278 IEA     complement-dependent cytotoxicity GO:0097278 ISO     complement-mediated synapse pruning GO:0150062 IEA     complement-mediated synapse pruning GO:0150062 ISO     vertebrate eye-specific patterning GO:0150064 IEA     vertebrate eye-specific patterning GO:0150064 ISO     positive regulation of apoptotic cell clearance GO:2000427 IEA     positive regulation of apoptotic cell clearance GO:2000427 ISO Subcellular Localization     extracellular region GO:0005576 ISO     extracellular space GO:0005615 IBA     extracellular space GO:0005615 IDA     extracellular space GO:0005615 IEA     extracellular space GO:0005615 ISO     cell surface GO:0009986 IEA     cell surface GO:0009986 ISO     protein-containing complex GO:0032991 IEA     protein-containing complex GO:0032991 ISO