Gene description for FRG1
Gene name FSHD region gene 1
Gene symbol FRG1
Other names/aliases FRG1A
FSG1
Species Homo sapiens
 Database cross references - FRG1
ExoCarta ExoCarta_2483
Vesiclepedia VP_2483
Entrez Gene 2483
HGNC 3954
MIM 601278
UniProt Q14331  
 FRG1 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for FRG1
Molecular Function
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
    actin filament binding GO:0051015 IBA
Biological Process
    mRNA splicing, via spliceosome GO:0000398 IC
    rRNA processing GO:0006364 IEA
    muscle organ development GO:0007517 IEA
Subcellular Localization
    nucleolus GO:0005730 IBA
    Cajal body GO:0015030 IEA
    Z disc GO:0030018 IEA
    striated muscle dense body GO:0055120 IBA
    catalytic step 2 spliceosome GO:0071013 IBA
    catalytic step 2 spliceosome GO:0071013 IDA
 Experiment description of studies that identified FRG1 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for FRG1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 HECTD1 25831
Affinity Capture-MS Homo sapiens
3 MECP2 4204
Affinity Capture-MS Homo sapiens
4 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
5 MYCN  
Affinity Capture-MS Homo sapiens
6 UBE2O 63893
Affinity Capture-MS Homo sapiens
7 RBPMS 11030
Two-hybrid Homo sapiens
8 COIL  
Proximity Label-MS Homo sapiens
9 Rrp1  
Two-hybrid Mus musculus
10 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
11 MEN1 4221
Affinity Capture-MS Homo sapiens
12 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
13 CAND1 55832
Affinity Capture-MS Homo sapiens
14 MKI67  
Affinity Capture-MS Homo sapiens
15 CENPA  
Proximity Label-MS Homo sapiens
16 LZTS2 84445
Two-hybrid Homo sapiens
17 Ksr1  
Affinity Capture-MS Mus musculus
18 MYC  
Affinity Capture-MS Homo sapiens
19 HECW2  
Affinity Capture-MS Homo sapiens
20 RPL31 6160
Proximity Label-MS Homo sapiens
21 GNMT 27232
Two-hybrid Homo sapiens
22 SART3 9733
Affinity Capture-MS Homo sapiens
23 EXOSC8  
Two-hybrid Homo sapiens
24 KRT40  
Two-hybrid Homo sapiens
25 DDRGK1 65992
Affinity Capture-MS Homo sapiens
26 CWC22 57703
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Two-hybrid Homo sapiens
27 RPA3 6119
Proximity Label-MS Homo sapiens
28 CEBPA  
Protein-peptide Homo sapiens
29 EP300 2033
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which FRG1 is involved
No pathways found





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