Gene description for SLC41A1
Gene name solute carrier family 41 (magnesium transporter), member 1
Gene symbol SLC41A1
Other names/aliases MgtE
Species Homo sapiens
 Database cross references - SLC41A1
ExoCarta ExoCarta_254428
Vesiclepedia VP_254428
Entrez Gene 254428
HGNC 19429
MIM 610801
UniProt Q8IVJ1  
 SLC41A1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for SLC41A1
Molecular Function
    protein binding GO:0005515 IPI
    magnesium ion transmembrane transporter activity GO:0015095 IDA
    magnesium ion transmembrane transporter activity GO:0015095 TAS
    transmembrane transporter activity GO:0022857 IDA
    transmembrane transporter activity GO:0022857 IMP
    inorganic cation transmembrane transporter activity GO:0022890 ISS
    magnesium:sodium antiporter activity GO:0061768 IMP
Biological Process
    intracellular magnesium ion homeostasis GO:0010961 IMP
    magnesium ion transport GO:0015693 IDA
    magnesium ion transport GO:0015693 IMP
    metal ion transport GO:0030001 ISS
    sodium ion transmembrane transport GO:0035725 IEA
    cellular response to magnesium ion GO:0071286 IGI
    cellular response to magnesium ion GO:0071286 ISS
    magnesium ion transmembrane transport GO:1903830 IDA
    magnesium ion transmembrane transport GO:1903830 ISS
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    basolateral plasma membrane GO:0016323 IDA
    protein-containing complex GO:0032991 IDA
 Experiment description of studies that identified SLC41A1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for SLC41A1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NT5E 4907
Affinity Capture-MS Homo sapiens
2 LYPD3 27076
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 SLC10A6  
Two-hybrid Homo sapiens
4 SSMEM1  
Two-hybrid Homo sapiens
5 GJA5 2702
Two-hybrid Homo sapiens
6 SYNDIG1  
Two-hybrid Homo sapiens
7 FFAR2  
Two-hybrid Homo sapiens
8 TMEM248 55069
Two-hybrid Homo sapiens
9 SLC35A5  
Affinity Capture-MS Homo sapiens
10 ERGIC3 51614
Two-hybrid Homo sapiens
11 GPR101  
Two-hybrid Homo sapiens
12 CLN5  
Two-hybrid Homo sapiens
13 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
14 CCDC155  
Two-hybrid Homo sapiens
15 CD79A  
Two-hybrid Homo sapiens
16 TRHR  
Two-hybrid Homo sapiens
17 FFAR3  
Two-hybrid Homo sapiens
18 AMIGO1  
Two-hybrid Homo sapiens
19 GPR152  
Two-hybrid Homo sapiens
20 SYPL2  
Two-hybrid Homo sapiens
21 GPR42  
Two-hybrid Homo sapiens
22 TAAR9  
Two-hybrid Homo sapiens
23 TMEM237 65062
Two-hybrid Homo sapiens
24 ELOVL7 79993
Two-hybrid Homo sapiens
25 SLC13A4  
Two-hybrid Homo sapiens
26 SLC10A1  
Two-hybrid Homo sapiens
27 TNFRSF10C  
Affinity Capture-MS Homo sapiens
28 OPRM1 4988
Two-hybrid Homo sapiens
29 TMEM56  
Two-hybrid Homo sapiens
30 LHFPL5  
Two-hybrid Homo sapiens
31 C19orf24  
Affinity Capture-MS Homo sapiens
32 GJB5  
Two-hybrid Homo sapiens
33 TMEM31  
Two-hybrid Homo sapiens
34 AVPR2  
Two-hybrid Homo sapiens
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