Gene description for GABRB2
Gene name gamma-aminobutyric acid (GABA) A receptor, beta 2
Gene symbol GABRB2
Other names/aliases -
Species Homo sapiens
 Database cross references - GABRB2
ExoCarta ExoCarta_2561
Vesiclepedia VP_2561
Entrez Gene 2561
HGNC 4082
MIM 600232
UniProt P47870  
 GABRB2 identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for GABRB2
Molecular Function
    GABA-A receptor activity GO:0004890 IBA
    GABA-A receptor activity GO:0004890 ISS
    chloride channel activity GO:0005254 IBA
    chloride channel activity GO:0005254 ISS
    GABA receptor activity GO:0016917 IMP
    GABA-gated chloride ion channel activity GO:0022851 IDA
    transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315 IEA
Biological Process
    gamma-aminobutyric acid signaling pathway GO:0007214 IDA
    gamma-aminobutyric acid signaling pathway GO:0007214 IMP
    gamma-aminobutyric acid signaling pathway GO:0007214 ISS
    gamma-aminobutyric acid signaling pathway GO:0007214 NAS
    chemical synaptic transmission GO:0007268 TAS
    synaptic transmission, GABAergic GO:0051932 ISS
    synaptic transmission, GABAergic GO:0051932 NAS
    regulation of postsynaptic membrane potential GO:0060078 IEA
    inner ear receptor cell development GO:0060119 IEA
    innervation GO:0060384 IEA
    cellular response to histamine GO:0071420 ISS
    cochlea development GO:0090102 IEA
    chloride transmembrane transport GO:1902476 IBA
    chloride transmembrane transport GO:1902476 IDA
    chloride transmembrane transport GO:1902476 ISS
    inhibitory synapse assembly GO:1904862 IDA
Subcellular Localization
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISS
    plasma membrane GO:0005886 TAS
    cytoplasmic vesicle membrane GO:0030659 IEA
    chloride channel complex GO:0034707 IEA
    dendritic spine GO:0043197 IDA
    postsynaptic membrane GO:0045211 IDA
    extracellular exosome GO:0070062 HDA
    GABA-ergic synapse GO:0098982 IEA
    postsynaptic specialization membrane GO:0099634 ISS
    GABA-A receptor complex GO:1902711 IBA
    GABA-A receptor complex GO:1902711 IPI
    GABA-A receptor complex GO:1902711 ISS
 Experiment description of studies that identified GABRB2 in sEVs
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for GABRB2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TP53 7157
Affinity Capture-MS Homo sapiens
2 TRAK2 66008
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
3 GABRB3 2562
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 UBQLN1 29979
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
5 ARHGEF25 115557
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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