Gene description for ZBTB20
Gene name zinc finger and BTB domain containing 20
Gene symbol ZBTB20
Other names/aliases DPZF
HOF
ODA-8S
PRIMS
ZNF288
Species Homo sapiens
 Database cross references - ZBTB20
ExoCarta ExoCarta_26137
Vesiclepedia VP_26137
Entrez Gene 26137
HGNC 13503
MIM 606025
UniProt Q9HC78  
 ZBTB20 identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ZBTB20
Molecular Function
    transcription cis-regulatory region binding GO:0000976 ISS
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IBA
    metal ion binding GO:0046872 IEA
    sequence-specific double-stranded DNA binding GO:1990837 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IBA
    regulation of cytokine production GO:0001817 IBA
    regulation of immune system process GO:0002682 IBA
    negative regulation of gene expression GO:0010629 IEA
    positive regulation of interferon-beta production GO:0032728 IEA
    positive regulation of interleukin-6 production GO:0032755 IEA
    positive regulation of tumor necrosis factor production GO:0032760 IEA
    positive regulation of glycolytic process GO:0045821 ISS
    positive regulation of lipid biosynthetic process GO:0046889 ISS
    lipid homeostasis GO:0055088 ISS
    cellular response to glucose stimulus GO:0071333 ISS
Subcellular Localization
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 IBA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 ISS
    nuclear body GO:0016604 IDA
 Experiment description of studies that identified ZBTB20 in sEVs
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ZBTB20
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ANLN 54443
Affinity Capture-MS Homo sapiens
2 FOXF2  
Affinity Capture-MS Homo sapiens
3 LIMA1 51474
Affinity Capture-MS Homo sapiens
4 SENP3 26168
Affinity Capture-MS Homo sapiens
5 TMEM132D  
Two-hybrid Homo sapiens
6 MECOM 2122
Affinity Capture-MS Homo sapiens
7 Myh9 17886
Affinity Capture-MS Mus musculus
8 Lima1  
Affinity Capture-MS Mus musculus
9 FLNA 2316
Affinity Capture-MS Homo sapiens
10 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
11 PPARG 5468
Two-hybrid Homo sapiens
12 MEF2BNB  
Affinity Capture-MS Homo sapiens
13 Calml3  
Affinity Capture-MS Mus musculus
14 DNAJB8 165721
Affinity Capture-MS Homo sapiens
15 NR3C1 2908
Two-hybrid Homo sapiens
16 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
17 MYO19  
Affinity Capture-MS Homo sapiens
18 TFPT  
Affinity Capture-MS Homo sapiens
19 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
20 SYNPO 11346
Affinity Capture-MS Homo sapiens
21 MYH9 4627
Affinity Capture-MS Homo sapiens
22 TRNAU1AP  
Affinity Capture-MS Homo sapiens
23 FAM212A  
Affinity Capture-MS Homo sapiens
24 CLASRP  
Affinity Capture-MS Homo sapiens
25 TEAD2  
Affinity Capture-MS Homo sapiens
26 CST11  
Affinity Capture-MS Homo sapiens
27 IQGAP1 8826
Affinity Capture-MS Homo sapiens
28 MBD3L1  
Affinity Capture-MS Homo sapiens
29 TWIST2  
Affinity Capture-MS Homo sapiens
30 CHD7  
Affinity Capture-MS Homo sapiens
31 HSPB8 26353
Affinity Capture-MS Homo sapiens
32 DACT2  
Affinity Capture-MS Homo sapiens
33 SYT11 23208
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ZBTB20 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here