Gene description for GRID1
Gene name glutamate receptor, ionotropic, delta 1
Gene symbol GRID1
Other names/aliases GluD1
Species Homo sapiens
 Database cross references - GRID1
ExoCarta ExoCarta_2894
Vesiclepedia VP_2894
Entrez Gene 2894
HGNC 4575
MIM 610659
UniProt Q9ULK0  
 GRID1 identified in sEVs derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Urine 19056867    
 Gene ontology annotations for GRID1
Molecular Function
    AMPA glutamate receptor activity GO:0004971 IBA
    protein binding GO:0005515 IPI
    GABA receptor activity GO:0016917 IDA
    identical protein binding GO:0042802 IEA
    G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential GO:0099530 IDA
    transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315 IBA
    transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315 ISS
Biological Process
    phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 IDA
    glutamate receptor signaling pathway GO:0007215 IEA
    negative regulation of synaptic plasticity GO:0031914 IDA
    monoatomic ion transmembrane transport GO:0034220 IEA
    social behavior GO:0035176 ISS
    synaptic transmission, glutamatergic GO:0035249 IBA
    modulation of chemical synaptic transmission GO:0050804 IBA
    regulation of postsynaptic membrane potential GO:0060078 IEA
    regulation of postsynaptic membrane neurotransmitter receptor levels GO:0099072 IEA
    regulation of postsynapse organization GO:0099175 IEA
    synaptic signaling via neuropeptide GO:0099538 IDA
    synaptic signaling via neuropeptide GO:0099538 ISS
Subcellular Localization
    plasma membrane GO:0005886 IBA
    AMPA glutamate receptor complex GO:0032281 IBA
    dendritic spine GO:0043197 IBA
    postsynaptic membrane GO:0045211 IDA
    postsynaptic membrane GO:0045211 ISS
    extracellular exosome GO:0070062 HDA
    trans-synaptic protein complex GO:0098820 ISS
    postsynaptic density membrane GO:0098839 IBA
    postsynaptic density membrane GO:0098839 ISS
    glutamatergic synapse GO:0098978 IEA
    GABA-ergic synapse GO:0098982 IEA
 Experiment description of studies that identified GRID1 in sEVs
1
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for GRID1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GRIA1  
Affinity Capture-MS Homo sapiens
2 HTR3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 CLEC12B  
Affinity Capture-MS Homo sapiens
4 PDGFRA 5156
Affinity Capture-MS Homo sapiens
5 KLRC1  
Affinity Capture-MS Homo sapiens
6 LILRB3  
Two-hybrid Homo sapiens
7 LGALS1 3956
Affinity Capture-MS Homo sapiens
8 EGFR 1956
Affinity Capture-MS Homo sapiens
9 DEF6 50619
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 HBB 3043
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 TCTN2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which GRID1 is involved
No pathways found





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