Gene description for Erlin2
Gene name ER lipid raft associated 2
Gene symbol Erlin2
Other names/aliases RGD1309010
Spfh2
Species Rattus norvegicus
 Database cross references - Erlin2
ExoCarta ExoCarta_290823
Vesiclepedia VP_290823
Entrez Gene 290823
UniProt B5DEH2  
 Erlin2 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Erlin2
Molecular Function
    cholesterol binding GO:0015485 IBA
    ubiquitin protein ligase binding GO:0031625 ISO
Biological Process
    cholesterol metabolic process GO:0008203 IEA
    SREBP signaling pathway GO:0032933 IBA
    SREBP signaling pathway GO:0032933 ISO
    ERAD pathway GO:0036503 ISO
    regulation of cholesterol biosynthetic process GO:0045540 ISO
    negative regulation of cholesterol biosynthetic process GO:0045541 ISO
    negative regulation of fatty acid biosynthetic process GO:0045717 ISO
Subcellular Localization
    endoplasmic reticulum GO:0005783 ISO
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum membrane GO:0005789 ISO
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    protein-containing complex GO:0032991 ISO
    membrane raft GO:0045121 ISO
 Experiment description of studies that identified Erlin2 in sEVs
1
Experiment ID 225
MISEV standards
EM
Biophysical techniques
GAPDH|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Erlin2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Aph1a  
Affinity Capture-Western Rattus norvegicus
2 Ncstn 289231
Affinity Capture-Western Rattus norvegicus
Affinity Capture-Western Rattus norvegicus
3 Psenen 292788
Affinity Capture-Western Rattus norvegicus
4 Itpr1  
Affinity Capture-Western Rattus norvegicus
5 Erlin1  
Affinity Capture-Western Rattus norvegicus
6 Dao  
Affinity Capture-MS Rattus norvegicus
7 Itm2b 290364
Affinity Capture-MS Rattus norvegicus
8 Psen1 29192
Affinity Capture-Western Rattus norvegicus
Affinity Capture-Western Rattus norvegicus
View the network image/svg+xml
 Pathways in which Erlin2 is involved
PathwayEvidenceSource
ABC-family proteins mediated transport IEA Reactome
Transport of small molecules IEA Reactome





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