Gene description for N6AMT1
Gene name N-6 adenine-specific DNA methyltransferase 1 (putative)
Gene symbol N6AMT1
Other names/aliases C21orf127
HEMK2
MTQ2
N6AMT
PRED28
m.HsaHemK2P
Species Homo sapiens
 Database cross references - N6AMT1
ExoCarta ExoCarta_29104
Vesiclepedia VP_29104
Entrez Gene 29104
HGNC 16021
MIM 614553
UniProt Q9Y5N5  
 N6AMT1 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for N6AMT1
Molecular Function
    nucleic acid binding GO:0003676 IEA
    protein binding GO:0005515 IPI
    protein methyltransferase activity GO:0008276 IBA
    protein methyltransferase activity GO:0008276 IDA
    S-adenosylmethionine-dependent methyltransferase activity GO:0008757 IBA
    site-specific DNA-methyltransferase (adenine-specific) activity GO:0009007 IDA
    site-specific DNA-methyltransferase (adenine-specific) activity GO:0009007 IDA
    arsenite methyltransferase activity GO:0030791 IDA
    protein-glutamine N-methyltransferase activity GO:0036009 IDA
    histone H4K12 methyltransferase activity GO:0140984 IDA
    S-adenosyl-L-methionine binding GO:1904047 IDA
Biological Process
    toxin metabolic process GO:0009404 IDA
    peptidyl-glutamine methylation GO:0018364 IDA
    arsonoacetate metabolic process GO:0018872 IDA
    positive regulation of cell growth GO:0030307 IDA
    methylation GO:0032259 IDA
    negative regulation of gene expression, epigenetic GO:0045814 IDA
    transcription initiation-coupled chromatin remodeling GO:0045815 IDA
Subcellular Localization
    nucleus GO:0005634 ISS
    cytosol GO:0005829 TAS
    protein-containing complex GO:0032991 IDA
    eRF1 methyltransferase complex GO:0035657 IBA
 Experiment description of studies that identified N6AMT1 in sEVs
1
Experiment ID 488
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for N6AMT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Cep85l  
Affinity Capture-MS Mus musculus
2 RIT1 6016
Negative Genetic Homo sapiens
3 RNASEH2A 10535
Affinity Capture-MS Homo sapiens
4 HSPA5 3309
Affinity Capture-MS Homo sapiens
5 Lyplal1  
Affinity Capture-MS Mus musculus
6 EGFR 1956
Negative Genetic Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here