Gene description for Nedd4l
Gene name neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
Gene symbol Nedd4l
Other names/aliases Nedd4-2
Species Rattus norvegicus
 Database cross references - Nedd4l
ExoCarta ExoCarta_291553
Vesiclepedia VP_291553
Entrez Gene 291553
 Nedd4l identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Nedd4l
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 IDA
    protein binding GO:0005515 IPI
    potassium channel regulator activity GO:0015459 ISO
    sodium channel regulator activity GO:0017080 ISO
    potassium channel inhibitor activity GO:0019870 IMP
    potassium channel inhibitor activity GO:0019870 ISO
    sodium channel inhibitor activity GO:0019871 IBA
    sodium channel inhibitor activity GO:0019871 ISO
    transmembrane transporter binding GO:0044325 ISO
    ubiquitin protein ligase activity GO:0061630 IBA
    ubiquitin protein ligase activity GO:0061630 ISO
Biological Process
    regulation of sodium ion transport GO:0002028 ISO
    negative regulation of systemic arterial blood pressure GO:0003085 ISO
    regulation of membrane depolarization GO:0003254 ISO
    ubiquitin-dependent protein catabolic process GO:0006511 IBA
    ubiquitin-dependent protein catabolic process GO:0006511 ISO
    protein monoubiquitination GO:0006513 IMP
    sodium ion transport GO:0006814 ISO
    response to salt stress GO:0009651 ISO
    positive regulation of sodium ion transport GO:0010765 ISO
    negative regulation of sodium ion transport GO:0010766 ISO
    protein ubiquitination GO:0016567 ISO
    regulation of protein stability GO:0031647 ISO
    regulation of monoatomic ion transmembrane transport GO:0034765 ISO
    regulation of membrane potential GO:0042391 ISO
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISO
    positive regulation of protein catabolic process GO:0045732 IMP
    regulation of dendrite morphogenesis GO:0048814 IBA
    establishment of localization in cell GO:0051649 ISO
    regulation of membrane repolarization GO:0060306 ISO
    protein K48-linked ubiquitination GO:0070936 ISO
    ventricular cardiac muscle cell action potential GO:0086005 IMP
    regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 ISO
    regulation protein catabolic process at postsynapse GO:0140252 ISO
    regulation of potassium ion transmembrane transporter activity GO:1901016 ISO
    negative regulation of potassium ion transmembrane transporter activity GO:1901017 IMP
    negative regulation of potassium ion transmembrane transporter activity GO:1901017 ISO
    negative regulation of potassium ion transmembrane transport GO:1901380 ISO
    regulation of sodium ion transmembrane transport GO:1902305 ISO
    negative regulation of sodium ion transmembrane transport GO:1902306 ISO
    negative regulation of sodium ion import across plasma membrane GO:1903783 ISO
    positive regulation of dendrite extension GO:1903861 ISO
    negative regulation of protein localization to cell surface GO:2000009 ISO
    negative regulation of sodium ion transmembrane transporter activity GO:2000650 ISO
    regulation of bicellular tight junction assembly GO:2000810 ISO
    positive regulation of cation channel activity GO:2001259 ISO
    positive regulation of caveolin-mediated endocytosis GO:2001288 IMP
Subcellular Localization
    cytoplasm GO:0005737 IBA
    plasma membrane GO:0005886 ISO
    apical plasma membrane GO:0016324 ISO
    postsynapse GO:0098794 IEA
    glutamatergic synapse GO:0098978 ISO
 Experiment description of studies that identified Nedd4l in sEVs
1
Experiment ID 225
MISEV standards
EM
Biophysical techniques
GAPDH|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Nedd4l
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TNK2 10188
Reconstituted Complex Homo sapiens
2 Hcn1  
Affinity Capture-Western Rattus norvegicus
3 APBB1  
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
4 Slc22a8  
Affinity Capture-Western Rattus norvegicus
View the network image/svg+xml
 Pathways in which Nedd4l is involved
No pathways found





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