Gene description for Atp2b4
Gene name	ATPase, Ca++ transporting, plasma membrane 4
Gene symbol	Atp2b4
Other names/aliases	PMCA4
Species	Rattus norvegicus
Database cross references - Atp2b4
ExoCarta	ExoCarta_29600
Vesiclepedia	VP_29600
Entrez Gene	29600
UniProt	Q64542
Atp2b4 identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Atp2b4

Molecular Function     P-type calcium transporter activity GO:0005388 IBA     P-type calcium transporter activity GO:0005388 IC     P-type calcium transporter activity GO:0005388 IDA     P-type calcium transporter activity GO:0005388 IEA     P-type calcium transporter activity GO:0005388 ISO     calmodulin binding GO:0005516 IEA     calmodulin binding GO:0005516 ISO     ATP binding GO:0005524 IEA     calcium ion transmembrane transporter activity GO:0015085 ISO     ATP hydrolysis activity GO:0016887 IEA     sodium channel regulator activity GO:0017080 ISO     protein kinase binding GO:0019901 IPI     PDZ domain binding GO:0030165 IPI     protein phosphatase 2B binding GO:0030346 ISO     nitric-oxide synthase inhibitor activity GO:0036487 ISO     metal ion binding GO:0046872 IEA     nitric-oxide synthase binding GO:0050998 ISO     scaffold protein binding GO:0097110 ISO Biological Process     neural retina development GO:0003407 IEP     regulation of transcription by RNA polymerase II GO:0006357 ISO     calcium ion transport GO:0006816 IDA     intracellular calcium ion homeostasis GO:0006874 ISO     intracellular calcium ion homeostasis GO:0006874 ISS     spermatogenesis GO:0007283 IEP     negative regulation of gene expression GO:0010629 ISO     urinary bladder smooth muscle contraction GO:0014832 ISO     urinary bladder smooth muscle contraction GO:0014832 ISS     negative regulation of angiogenesis GO:0016525 ISO     hippocampus development GO:0021766 IEP     flagellated sperm motility GO:0030317 ISO     flagellated sperm motility GO:0030317 ISS     nitric oxide-cGMP-mediated signaling GO:0038060 ISO     negative regulation of blood vessel endothelial cell migration GO:0043537 ISO     negative regulation of nitric oxide biosynthetic process GO:0045019 ISO     negative regulation of nitric-oxide synthase activity GO:0051001 ISO     regulation of cytosolic calcium ion concentration GO:0051480 IBA     response to hydrostatic pressure GO:0051599 ISO     calcium ion transmembrane transport GO:0070588 IEA     calcium ion transmembrane transport GO:0070588 IMP     calcium ion transmembrane transport GO:0070588 ISO     negative regulation of calcineurin-NFAT signaling cascade GO:0070885 IMP     negative regulation of calcineurin-NFAT signaling cascade GO:0070885 ISO     cellular response to epinephrine stimulus GO:0071872 ISO     negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071878 ISO     negative regulation of the force of heart contraction GO:0098736 ISO     negative regulation of arginine catabolic process GO:1900082 ISO     calcium ion export GO:1901660 IMP     calcium ion export GO:1901660 ISO     negative regulation of cellular response to vascular endothelial growth factor stimulus GO:1902548 ISO     regulation of cell cycle G1/S phase transition GO:1902806 ISO     positive regulation of protein localization to plasma membrane GO:1903078 ISO     negative regulation of cardiac muscle hypertrophy in response to stress GO:1903243 ISO     negative regulation of citrulline biosynthetic process GO:1903249 ISO     cellular response to acetylcholine GO:1905145 ISO     cellular response to acetylcholine GO:1905145 ISS Subcellular Localization     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IEA     plasma membrane GO:0005886 ISO     membrane GO:0016020 ISO     basolateral plasma membrane GO:0016323 IDA     Z disc GO:0030018 ISO     T-tubule GO:0030315 ISO     protein-containing complex GO:0032991 ISO     sperm flagellum GO:0036126 ISO     sarcolemma GO:0042383 ISO     intracellular membrane-bounded organelle GO:0043231 IBA     membrane raft GO:0045121 ISO     presynaptic active zone membrane GO:0048787 EXP     presynaptic active zone membrane GO:0048787 IDA     sperm principal piece GO:0097228 IDA     glutamatergic synapse GO:0098978 EXP     glutamatergic synapse GO:0098978 IDA