Gene description for Gsn
Gene name	gelsolin
Gene symbol	Gsn
Other names/aliases	-
Species	Rattus norvegicus
Database cross references - Gsn
ExoCarta	ExoCarta_296654
Vesiclepedia	VP_296654
Entrez Gene	296654
UniProt	Q68FP1
Gsn identified in sEVs derived from the following tissue/cell type
Cortical neurones	16446100
Pancreatic cancer cells	20124479
Pancreatic cancer cells	20124479
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Gsn

Molecular Function     actin binding GO:0003779 IDA     actin binding GO:0003779 ISO     calcium ion binding GO:0005509 IEA     calcium ion binding GO:0005509 ISO     phosphatidylinositol-4,5-bisphosphate binding GO:0005546 IBA     phosphatidylinositol 3-kinase catalytic subunit binding GO:0036313 IEA     phosphatidylinositol 3-kinase catalytic subunit binding GO:0036313 ISO     myosin II binding GO:0045159 IEA     myosin II binding GO:0045159 ISO     actin filament binding GO:0051015 IBA     actin filament binding GO:0051015 IEA Biological Process     phagocytosis, engulfment GO:0006911 IEA     phagocytosis, engulfment GO:0006911 ISO     actin filament organization GO:0007015 ISO     central nervous system development GO:0007417 IBA     actin polymerization or depolymerization GO:0008154 IBA     actin polymerization or depolymerization GO:0008154 IDA     positive regulation of cardiac muscle hypertrophy GO:0010613 IMP     positive regulation of gene expression GO:0010628 ISO     oligodendrocyte development GO:0014003 IEP     striated muscle atrophy GO:0014891 IEA     striated muscle atrophy GO:0014891 ISO     vesicle-mediated transport GO:0016192 ISO     extracellular matrix disassembly GO:0022617 ISO     cell projection assembly GO:0030031 IBA     actin cytoskeleton organization GO:0030036 ISO     actin filament polymerization GO:0030041 IEA     actin filament polymerization GO:0030041 ISO     actin filament polymerization GO:0030041 ISS     actin filament depolymerization GO:0030042 IEA     actin filament depolymerization GO:0030042 IMP     actin filament depolymerization GO:0030042 ISO     protein destabilization GO:0031648 IEA     protein destabilization GO:0031648 ISO     response to muscle stretch GO:0035994 IEA     response to muscle stretch GO:0035994 ISO     tissue regeneration GO:0042246 IEP     sequestering of actin monomers GO:0042989 IEA     sequestering of actin monomers GO:0042989 ISO     response to ethanol GO:0045471 IEP     negative regulation of viral entry into host cell GO:0046597 IEA     actin filament severing GO:0051014 IBA     actin filament severing GO:0051014 IEA     actin filament severing GO:0051014 ISO     actin filament severing GO:0051014 ISS     barbed-end actin filament capping GO:0051016 IBA     barbed-end actin filament capping GO:0051016 IEA     positive regulation of actin nucleation GO:0051127 IEA     positive regulation of actin nucleation GO:0051127 ISO     response to folic acid GO:0051593 IEP     actin filament capping GO:0051693 ISO     relaxation of cardiac muscle GO:0055119 IEA     relaxation of cardiac muscle GO:0055119 ISO     cilium assembly GO:0060271 IEA     cilium assembly GO:0060271 ISO     cilium assembly GO:0060271 ISS     cellular response to cadmium ion GO:0071276 IDA     cellular response to type II interferon GO:0071346 IEA     cellular response to type II interferon GO:0071346 ISO     regulation of podosome assembly GO:0071801 IEA     regulation of podosome assembly GO:0071801 ISO     cardiac muscle cell contraction GO:0086003 IEA     cardiac muscle cell contraction GO:0086003 ISO     renal protein absorption GO:0097017 IEA     renal protein absorption GO:0097017 ISO     hepatocyte apoptotic process GO:0097284 IEA     hepatocyte apoptotic process GO:0097284 ISO     positive regulation of p38MAPK cascade GO:1900745 IMP     positive regulation of keratinocyte apoptotic process GO:1902174 IEA     positive regulation of keratinocyte apoptotic process GO:1902174 ISO     regulation of establishment of T cell polarity GO:1903903 IEA     regulation of establishment of T cell polarity GO:1903903 ISO     regulation of plasma membrane raft polarization GO:1903906 IEA     regulation of plasma membrane raft polarization GO:1903906 ISO     regulation of receptor clustering GO:1903909 IEA     regulation of receptor clustering GO:1903909 ISO     positive regulation of protein processing in phagocytic vesicle GO:1903923 IEA     positive regulation of protein processing in phagocytic vesicle GO:1903923 ISO     amyloid fibril formation GO:1990000 IEA     amyloid fibril formation GO:1990000 ISO     positive regulation of cysteine-type endopeptidase activity GO:2001056 ISO Subcellular Localization     ruffle GO:0001726 IDA     podosome GO:0002102 IEA     podosome GO:0002102 ISO     extracellular region GO:0005576 ISO     extracellular region GO:0005576 ISS     extracellular space GO:0005615 IBA     extracellular space GO:0005615 IDA     extracellular space GO:0005615 IEA     extracellular space GO:0005615 ISO     nucleus GO:0005634 IEA     nucleus GO:0005634 ISO     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 IEA     cytoplasm GO:0005737 ISO     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     cytosol GO:0005829 ISS     cytoskeleton GO:0005856 IEA     plasma membrane GO:0005886 IEA     plasma membrane GO:0005886 ISO     focal adhesion GO:0005925 IEA     focal adhesion GO:0005925 ISO     actin cytoskeleton GO:0015629 IBA     actin cytoskeleton GO:0015629 IDA     sarcoplasm GO:0016528 IEA     sarcoplasm GO:0016528 ISO     lamellipodium GO:0030027 IEA     lamellipodium GO:0030027 ISO     actin cap GO:0030478 IEA     actin cap GO:0030478 ISO     cortical actin cytoskeleton GO:0030864 ISO     protein-containing complex GO:0032991 IDA     myelin sheath GO:0043209 IDA     phagocytic vesicle GO:0045335 IEA     phagocytic vesicle GO:0045335 ISO     perinuclear region of cytoplasm GO:0048471 IDA     apical ectoplasmic specialization GO:0061831 IDA     basal ectoplasmic specialization GO:0061832 IDA     glial filament GO:0097426 IDA