Gene description for C1qbp
Gene name complement component 1, q subcomponent binding protein
Gene symbol C1qbp
Other names/aliases Habp1
gC1qR
Species Rattus norvegicus
 Database cross references - C1qbp
ExoCarta ExoCarta_29681
Vesiclepedia VP_29681
Entrez Gene 29681
UniProt O35796  
 C1qbp identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for C1qbp
Molecular Function
    complement component C1q complex binding GO:0001849 IBA
    complement component C1q complex binding GO:0001849 IDA
    complement component C1q complex binding GO:0001849 IEA
    complement component C1q complex binding GO:0001849 ISO
    transcription corepressor activity GO:0003714 IBA
    transcription corepressor activity GO:0003714 IEA
    transcription corepressor activity GO:0003714 ISO
    transcription corepressor activity GO:0003714 ISS
    mRNA binding GO:0003729 ISO
    mRNA binding GO:0003729 ISS
    enzyme inhibitor activity GO:0004857 ISO
    enzyme inhibitor activity GO:0004857 ISS
    protein kinase C binding GO:0005080 IDA
    protein binding GO:0005515 IPI
    hyaluronic acid binding GO:0005540 IEA
    hyaluronic acid binding GO:0005540 ISO
    hyaluronic acid binding GO:0005540 ISS
    kininogen binding GO:0030984 IBA
    kininogen binding GO:0030984 IEA
    kininogen binding GO:0030984 ISO
    kininogen binding GO:0030984 ISS
    adrenergic receptor binding GO:0031690 IDA
    deoxyribonuclease inhibitor activity GO:0060703 IEA
    deoxyribonuclease inhibitor activity GO:0060703 ISO
    C5-methylcytidine-containing RNA reader activity GO:0062153 IEA
    C5-methylcytidine-containing RNA reader activity GO:0062153 ISO
    mitochondrial ribosome binding GO:0097177 ISO
    mitochondrial ribosome binding GO:0097177 ISS
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IEA
    negative regulation of transcription by RNA polymerase II GO:0000122 ISO
    negative regulation of transcription by RNA polymerase II GO:0000122 ISS
    mitochondrial RNA catabolic process GO:0000957 IEA
    mitochondrial RNA catabolic process GO:0000957 ISO
    mRNA processing GO:0006397 IEA
    apoptotic process GO:0006915 IEA
    immune response GO:0006955 TAS
    complement activation, classical pathway GO:0006958 IEA
    DNA damage response GO:0006974 IEA
    RNA splicing GO:0008380 IEA
    regulation of complement activation GO:0030449 IBA
    regulation of complement activation GO:0030449 IEA
    regulation of complement activation GO:0030449 ISO
    regulation of complement activation GO:0030449 ISS
    negative regulation of type II interferon production GO:0032689 IEA
    negative regulation of type II interferon production GO:0032689 ISO
    negative regulation of type II interferon production GO:0032689 ISS
    negative regulation of interleukin-12 production GO:0032695 IEA
    negative regulation of interleukin-12 production GO:0032695 ISO
    negative regulation of interleukin-12 production GO:0032695 ISS
    negative regulation of MDA-5 signaling pathway GO:0039534 IEA
    negative regulation of MDA-5 signaling pathway GO:0039534 ISO
    negative regulation of MDA-5 signaling pathway GO:0039534 ISS
    negative regulation of RIG-I signaling pathway GO:0039536 IEA
    negative regulation of RIG-I signaling pathway GO:0039536 ISO
    negative regulation of RIG-I signaling pathway GO:0039536 ISS
    cytosolic ribosome assembly GO:0042256 IBA
    cytosolic ribosome assembly GO:0042256 IEA
    cytosolic ribosome assembly GO:0042256 ISO
    cytosolic ribosome assembly GO:0042256 ISS
    positive regulation of apoptotic process GO:0043065 IEA
    positive regulation of apoptotic process GO:0043065 ISO
    positive regulation of apoptotic process GO:0043065 ISS
    phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 IEA
    phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 ISO
    phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 ISS
    innate immune response GO:0045087 IEA
    positive regulation of cell adhesion GO:0045785 ISO
    positive regulation of cell adhesion GO:0045785 ISS
    negative regulation of mRNA splicing, via spliceosome GO:0048025 IBA
    negative regulation of mRNA splicing, via spliceosome GO:0048025 IEA
    negative regulation of mRNA splicing, via spliceosome GO:0048025 ISO
    negative regulation of mRNA splicing, via spliceosome GO:0048025 ISS
    negative regulation of defense response to virus GO:0050687 IEA
    negative regulation of defense response to virus GO:0050687 ISO
    negative regulation of defense response to virus GO:0050687 ISS
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IEA
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISO
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISS
    positive regulation of mitochondrial translation GO:0070131 ISO
    positive regulation of mitochondrial translation GO:0070131 ISS
    positive regulation of neutrophil chemotaxis GO:0090023 IEA
    positive regulation of neutrophil chemotaxis GO:0090023 ISO
    positive regulation of neutrophil chemotaxis GO:0090023 ISS
    positive regulation of substrate adhesion-dependent cell spreading GO:1900026 IEA
    positive regulation of substrate adhesion-dependent cell spreading GO:1900026 ISO
    positive regulation of substrate adhesion-dependent cell spreading GO:1900026 ISS
    positive regulation of trophoblast cell migration GO:1901165 IEA
    positive regulation of trophoblast cell migration GO:1901165 ISO
    positive regulation of trophoblast cell migration GO:1901165 ISS
    negative regulation of double-strand break repair via homologous recombination GO:2000042 IEA
    negative regulation of double-strand break repair via homologous recombination GO:2000042 ISO
    negative regulation of double-strand break repair via homologous recombination GO:2000042 ISS
    positive regulation of dendritic cell chemotaxis GO:2000510 IEA
    positive regulation of dendritic cell chemotaxis GO:2000510 ISO
    positive regulation of dendritic cell chemotaxis GO:2000510 ISS
Subcellular Localization
    extracellular space GO:0005615 IDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IEA
    nucleus GO:0005634 ISO
    nucleolus GO:0005730 IEA
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 ISO
    mitochondrial matrix GO:0005759 IEA
    mitochondrial matrix GO:0005759 ISO
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    cell surface GO:0009986 IBA
    cell surface GO:0009986 IEA
    cell surface GO:0009986 ISO
    membrane GO:0016020 ISO
    presynaptic active zone GO:0048786 EXP
    presynaptic active zone GO:0048786 IDA
    glutamatergic synapse GO:0098978 EXP
    glutamatergic synapse GO:0098978 IDA
    GABA-ergic synapse GO:0098982 EXP
    GABA-ergic synapse GO:0098982 IDA
 Experiment description of studies that identified C1qbp in sEVs
1
Experiment ID 90
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E"
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 94
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
3
Experiment ID 95
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
4
Experiment ID 96
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
5
Experiment ID 97
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
6
Experiment ID 98
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
7
Experiment ID 100
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [QSTAR]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
8
Experiment ID 101
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [QSTAR]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for C1qbp
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Dao  
Affinity Capture-MS Rattus norvegicus
2 Mib1  
Affinity Capture-MS Rattus norvegicus
3 STXBP5L  
Affinity Capture-MS Homo sapiens
4 Itm2b 290364
Affinity Capture-MS Rattus norvegicus
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