Gene description for ZDHHC8
Gene name zinc finger, DHHC-type containing 8
Gene symbol ZDHHC8
Other names/aliases DHHC8
ZDHHCL1
ZNF378
Species Homo sapiens
 Database cross references - ZDHHC8
ExoCarta ExoCarta_29801
Vesiclepedia VP_29801
Entrez Gene 29801
HGNC 18474
MIM 608784
UniProt Q9ULC8  
 ZDHHC8 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for ZDHHC8
Molecular Function
    palmitoyltransferase activity GO:0016409 IBA
    palmitoyltransferase activity GO:0016409 IDA
    protein-cysteine S-palmitoyltransferase activity GO:0019706 IC
    protein-cysteine S-palmitoyltransferase activity GO:0019706 TAS
Biological Process
    locomotory behavior GO:0007626 IEA
    positive regulation of cholesterol efflux GO:0010875 IBA
    positive regulation of cholesterol efflux GO:0010875 IDA
    peptidyl-L-cysteine S-palmitoylation GO:0018230 IDA
    protein palmitoylation GO:0018345 IDA
    high-density lipoprotein particle assembly GO:0034380 TAS
    positive regulation by host of viral process GO:0044794 IDA
    regulation of postsynapse assembly GO:0150052 IEA
    positive regulation of protein localization to plasma membrane GO:1903078 IC
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    cytosol GO:0005829 TAS
    mitochondrial membrane GO:0031966 IEA
    postsynapse GO:0098794 IEA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified ZDHHC8 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ZDHHC8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LYN 4067
Proximity Label-MS Homo sapiens
2 PARD3 56288
Proximity Label-MS Homo sapiens
3 RNF43  
Proximity Label-MS Homo sapiens
4 KRAS 3845
Proximity Label-MS Homo sapiens
5 CLDND1 56650
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 MCAM 4162
Proximity Label-MS Homo sapiens
7 CAV1 857
Proximity Label-MS Homo sapiens
8 ARF6 382
Proximity Label-MS Homo sapiens
9 GJA1 2697
Proximity Label-MS Homo sapiens
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