Gene description for HOXB6
Gene name homeobox B6
Gene symbol HOXB6
Other names/aliases HOX2
HOX2B
HU-2
Hox-2.2
Species Homo sapiens
 Database cross references - HOXB6
ExoCarta ExoCarta_3216
Vesiclepedia VP_3216
Entrez Gene 3216
HGNC 5117
MIM 142961
UniProt P17509  
 HOXB6 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for HOXB6
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
    sequence-specific double-stranded DNA binding GO:1990837 IDA
Biological Process
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    anterior/posterior pattern specification GO:0009952 IBA
    erythrocyte homeostasis GO:0034101 IEA
    embryonic skeletal system morphogenesis GO:0048704 IEA
Subcellular Localization
    chromatin GO:0000785 ISA
    nucleus GO:0005634 IBA
 Experiment description of studies that identified HOXB6 in sEVs
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for HOXB6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 TRAPPC6B 122553
Affinity Capture-MS Homo sapiens
3 NAGK 55577
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 TRAPPC9 83696
Affinity Capture-MS Homo sapiens
5 TCF21  
Two-hybrid Homo sapiens
6 C7orf43  
Affinity Capture-MS Homo sapiens
7 LRRC1 55227
Affinity Capture-MS Homo sapiens
8 S100P 6286
Affinity Capture-MS Homo sapiens
9 TRAPPC5 126003
Affinity Capture-MS Homo sapiens
10 TRAPPC10 7109
Affinity Capture-MS Homo sapiens
11 DCAF17  
Affinity Capture-MS Homo sapiens
12 CANX 821
Affinity Capture-MS Homo sapiens
13 AHCYL1 10768
Affinity Capture-MS Homo sapiens
14 CLK3  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
15 KCTD10 83892
Affinity Capture-MS Homo sapiens
16 NEK6 10783
Two-hybrid Homo sapiens
17 PSME3 10197
Affinity Capture-MS Homo sapiens
18 TRAF7  
Affinity Capture-MS Homo sapiens
19 GPX1 2876
Affinity Capture-MS Homo sapiens
20 ERBB2IP 55914
Affinity Capture-MS Homo sapiens
21 PRRC2A 7916
Affinity Capture-MS Homo sapiens
22 RNH1 6050
Affinity Capture-MS Homo sapiens
23 KCTD9  
Affinity Capture-MS Homo sapiens
24 C4A 720
Affinity Capture-MS Homo sapiens
25 TEKT5  
Two-hybrid Homo sapiens
26 GGPS1  
Affinity Capture-MS Homo sapiens
27 PLSCR1 5359
Two-hybrid Homo sapiens
28 SRPK2 6733
Two-hybrid Homo sapiens
29 CREBBP  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
30 KBTBD6  
Affinity Capture-MS Homo sapiens
31 TCEAL1  
Two-hybrid Homo sapiens
32 KBTBD7  
Affinity Capture-MS Homo sapiens
33 ANKRD17 26057
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 SDE2  
Affinity Capture-MS Homo sapiens
35 AHCYL2 23382
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 KRT15 3866
Two-hybrid Homo sapiens
37 ANKHD1 54882
Affinity Capture-MS Homo sapiens
38 GLUL 2752
Affinity Capture-MS Homo sapiens
39 WDYHV1  
Two-hybrid Homo sapiens
40 ANKHD1-EIF4EBP3  
Affinity Capture-MS Homo sapiens
41 TRAPPC4 51399
Affinity Capture-MS Homo sapiens
42 TRAPPC3 27095
Affinity Capture-MS Homo sapiens
43 GYS1 2997
Two-hybrid Homo sapiens
44 DCAF10  
Affinity Capture-MS Homo sapiens
45 TMED7 51014
Affinity Capture-MS Homo sapiens
46 MAPK14 1432
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 DDOST 1650
Affinity Capture-MS Homo sapiens
48 SAT1  
Two-hybrid Homo sapiens
49 OST4  
Affinity Capture-MS Homo sapiens
50 ALX4  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which HOXB6 is involved
No pathways found





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