Gene description for SLC35D3
Gene name solute carrier family 35, member D3
Gene symbol SLC35D3
Other names/aliases FRCL1
Species Homo sapiens
 Database cross references - SLC35D3
ExoCarta ExoCarta_340146
Vesiclepedia VP_340146
Entrez Gene 340146
HGNC 15621
MIM 612519
UniProt Q5M8T2  
 SLC35D3 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for SLC35D3
Molecular Function
    UDP-glucose transmembrane transporter activity GO:0005460 IDA
    protein binding GO:0005515 IPI
    antiporter activity GO:0015297 IBA
    protein-macromolecule adaptor activity GO:0030674 ISS
Biological Process
    positive regulation of autophagy GO:0010508 ISS
    UDP-glucose transmembrane transport GO:0015786 IDA
    protein exit from endoplasmic reticulum GO:0032527 IEA
    transmembrane transport GO:0055085 IBA
    platelet dense granule organization GO:0060155 ISS
    positive regulation of protein exit from endoplasmic reticulum GO:0070863 IEA
    energy homeostasis GO:0097009 IEA
Subcellular Localization
    endoplasmic reticulum GO:0005783 ISS
    endoplasmic reticulum membrane GO:0005789 IEA
    Golgi apparatus GO:0005794 IBA
    synaptic vesicle membrane GO:0030672 IDA
    early endosome membrane GO:0031901 ISS
 Experiment description of studies that identified SLC35D3 in sEVs
1
Experiment ID 235
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for SLC35D3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATP6V0A1 535
Affinity Capture-MS Homo sapiens
2 GPCPD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SLC35D3 is involved
No pathways found





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