Gene description for Ank3
Gene name ankyrin 3, node of Ranvier (ankyrin G)
Gene symbol Ank3
Other names/aliases ANK-3
Species Rattus norvegicus
 Database cross references - Ank3
ExoCarta ExoCarta_361833
Vesiclepedia VP_361833
Entrez Gene 361833
UniProt O70511  
 Ank3 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Ank3
Molecular Function
    structural constituent of cytoskeleton GO:0005200 IEA
    structural constituent of cytoskeleton GO:0005200 ISO
    protein binding GO:0005515 IPI
    cytoskeletal protein binding GO:0008092 IBA
    cytoskeletal protein binding GO:0008092 IPI
    spectrin binding GO:0030507 IDA
    protein-macromolecule adaptor activity GO:0030674 IBA
    protein-macromolecule adaptor activity GO:0030674 IDA
    transmembrane transporter binding GO:0044325 IBA
    transmembrane transporter binding GO:0044325 IPI
    transmembrane transporter binding GO:0044325 ISO
    cadherin binding GO:0045296 IPI
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IBA
    phosphorylation-dependent protein binding GO:0140031 IPI
Biological Process
    mitotic cytokinesis GO:0000281 IEA
    mitotic cytokinesis GO:0000281 ISO
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    plasma membrane organization GO:0007009 IEA
    plasma membrane organization GO:0007009 ISO
    cytoskeleton organization GO:0007010 IEA
    signal transduction GO:0007165 IEA
    axonogenesis GO:0007409 ISO
    axon guidance GO:0007411 ISO
    neuromuscular junction development GO:0007528 IEP
    anterograde axonal transport GO:0008089 IMP
    positive regulation of gene expression GO:0010628 IMP
    positive regulation of cell communication by electrical coupling GO:0010650 IMP
    positive regulation of sodium ion transport GO:0010765 IMP
    magnesium ion homeostasis GO:0010960 ISO
    magnesium ion homeostasis GO:0010960 ISS
    neuronal action potential GO:0019228 ISO
    establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 IMP
    maintenance of protein location in cell GO:0032507 IMP
    positive regulation of homotypic cell-cell adhesion GO:0034112 IMP
    response to immobilization stress GO:0035902 IEP
    Golgi to plasma membrane protein transport GO:0043001 IEA
    Golgi to plasma membrane protein transport GO:0043001 ISO
    regulation of potassium ion transport GO:0043266 IDA
    clustering of voltage-gated sodium channels GO:0045162 IMP
    establishment of protein localization GO:0045184 ISO
    negative regulation of endocytosis GO:0045806 IMP
    positive regulation of membrane potential GO:0045838 IMP
    synapse organization GO:0050808 ISO
    axon development GO:0061564 IMP
    cellular response to magnesium ion GO:0071286 ISO
    cellular response to magnesium ion GO:0071286 ISS
    membrane assembly GO:0071709 IEA
    membrane assembly GO:0071709 IGI
    membrane assembly GO:0071709 ISO
    protein localization to plasma membrane GO:0072659 IBA
    protein localization to plasma membrane GO:0072659 IGI
    protein localization to plasma membrane GO:0072659 IMP
    protein localization to plasma membrane GO:0072659 ISO
    maintenance of protein location in plasma membrane GO:0072660 IEA
    maintenance of protein location in plasma membrane GO:0072660 ISO
    positive regulation of protein targeting to membrane GO:0090314 IMP
    regulation of modification of postsynaptic structure GO:0099159 IDA
    regulation of modification of postsynaptic structure GO:0099159 IMP
    protein localization to axon GO:0099612 IMP
    protein localization to axon GO:0099612 ISO
    positive regulation of membrane depolarization during cardiac muscle cell action potential GO:1900827 IMP
    positive regulation of non-canonical NF-kappaB signal transduction GO:1901224 IMP
    negative regulation of delayed rectifier potassium channel activity GO:1902260 ISO
    negative regulation of delayed rectifier potassium channel activity GO:1902260 ISS
    regulation of protein targeting GO:1903533 IMP
    positive regulation of sodium ion import across plasma membrane GO:1903784 IMP
    positive regulation of sodium ion transmembrane transporter activity GO:2000651 IMP
    positive regulation of cation channel activity GO:2001259 IMP
Subcellular Localization
    nucleus GO:0005634 IBA
    lysosome GO:0005764 IEA
    cytoskeleton GO:0005856 IBA
    cytoskeleton GO:0005856 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    bicellular tight junction GO:0005923 IEA
    bicellular tight junction GO:0005923 ISO
    basal plasma membrane GO:0009925 ISO
    cell surface GO:0009986 IDA
    postsynaptic density GO:0014069 ISO
    intercalated disc GO:0014704 IDA
    intercalated disc GO:0014704 ISO
    spectrin-associated cytoskeleton GO:0014731 IDA
    membrane GO:0016020 IEA
    membrane GO:0016020 ISO
    basolateral plasma membrane GO:0016323 IEA
    basolateral plasma membrane GO:0016323 ISO
    lateral plasma membrane GO:0016328 IEA
    lateral plasma membrane GO:0016328 ISO
    sarcoplasmic reticulum GO:0016529 IDA
    Z disc GO:0030018 IDA
    T-tubule GO:0030315 IDA
    axon GO:0030424 IDA
    axon GO:0030424 ISO
    dendrite GO:0030425 IDA
    neuromuscular junction GO:0031594 IDA
    node of Ranvier GO:0033268 IDA
    node of Ranvier GO:0033268 ISO
    paranode region of axon GO:0033270 ISO
    sarcolemma GO:0042383 IDA
    sarcolemma GO:0042383 IEA
    sarcolemma GO:0042383 ISO
    neuron projection GO:0043005 IBA
    costamere GO:0043034 IDA
    costamere GO:0043034 TAS
    axon initial segment GO:0043194 IDA
    axon initial segment GO:0043194 IEA
    axon initial segment GO:0043194 IMP
    axon initial segment GO:0043194 ISO
    synapse GO:0045202 ISO
    postsynaptic membrane GO:0045211 IDA
    postsynapse GO:0098794 IDA
    postsynapse GO:0098794 IMP
    postsynapse GO:0098794 ISO
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IMP
    axon cytoplasm GO:1904115 IEA
 Experiment description of studies that identified Ank3 in sEVs
1
Experiment ID 94
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Ank3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Itm2b 290364
Affinity Capture-MS Rattus norvegicus
View the network image/svg+xml
 Pathways in which Ank3 is involved
No pathways found





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