Gene description for Hnrnpa2b1
Gene name heterogeneous nuclear ribonucleoprotein A2/B1
Gene symbol Hnrnpa2b1
Other names/aliases Hnrpa2
Hnrpa2b1
hnRNP
Species Rattus norvegicus
 Database cross references - Hnrnpa2b1
ExoCarta ExoCarta_362361
Vesiclepedia VP_362361
Entrez Gene 362361
UniProt A7VJC2  
 Hnrnpa2b1 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Hnrnpa2b1
Molecular Function
    regulatory region RNA binding GO:0001069 IDA
    RNA binding GO:0003723 IDA
    RNA binding GO:0003723 IEA
    RNA binding GO:0003723 ISO
    mRNA 3'-UTR binding GO:0003730 IBA
    mRNA 3'-UTR binding GO:0003730 IDA
    mRNA 3'-UTR binding GO:0003730 IEA
    mRNA 3'-UTR binding GO:0003730 ISO
    protein binding GO:0005515 IPI
    miRNA binding GO:0035198 IEA
    miRNA binding GO:0035198 ISO
    miRNA binding GO:0035198 ISS
    identical protein binding GO:0042802 ISO
    single-stranded telomeric DNA binding GO:0043047 IBA
    single-stranded telomeric DNA binding GO:0043047 IDA
    single-stranded telomeric DNA binding GO:0043047 IEA
    single-stranded telomeric DNA binding GO:0043047 ISO
    DNA polymerase binding GO:0070182 IPI
    pre-mRNA intronic binding GO:0097157 ISO
    G-rich strand telomeric DNA binding GO:0098505 IDA
    molecular condensate scaffold activity GO:0140693 IEA
    molecular condensate scaffold activity GO:0140693 ISO
    N6-methyladenosine-containing RNA reader activity GO:1990247 IEA
    N6-methyladenosine-containing RNA reader activity GO:1990247 ISO
    N6-methyladenosine-containing RNA reader activity GO:1990247 ISS
    mRNA CDS binding GO:1990715 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 ISO
    mRNA splicing, via spliceosome GO:0000398 IBA
    mRNA splicing, via spliceosome GO:0000398 IEA
    mRNA splicing, via spliceosome GO:0000398 ISO
    mRNA splicing, via spliceosome GO:0000398 ISS
    mRNA processing GO:0006397 ISO
    mRNA export from nucleus GO:0006406 IDA
    mRNA export from nucleus GO:0006406 IEA
    mRNA export from nucleus GO:0006406 ISO
    male gonad development GO:0008584 IEP
    telomere capping GO:0016233 IDA
    lung development GO:0030324 IEP
    primary miRNA processing GO:0031053 IEA
    primary miRNA processing GO:0031053 ISO
    primary miRNA processing GO:0031053 ISS
    G-quadruplex DNA unwinding GO:0044806 IDA
    negative regulation of mRNA splicing, via spliceosome GO:0048025 ISO
    oligodendrocyte differentiation GO:0048709 IEP
    RNA transport GO:0050658 IMP
    RNA transport GO:0050658 ISO
    mRNA transport GO:0051028 IBA
    mRNA transport GO:0051028 IEA
    response to mineralocorticoid GO:0051385 IEP
    positive regulation of telomere maintenance via telomere lengthening GO:1904358 IDA
    miRNA transport GO:1990428 IEA
    miRNA transport GO:1990428 ISO
    miRNA transport GO:1990428 ISS
Subcellular Localization
    chromosome, telomeric region GO:0000781 IDA
    chromatin GO:0000785 IDA
    extracellular region GO:0005576 IEA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 IEA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    spliceosomal complex GO:0005681 ISO
    cytoplasm GO:0005737 IEA
    cytoplasm GO:0005737 ISO
    postsynaptic density GO:0014069 EXP
    postsynaptic density GO:0014069 IDA
    Cajal body GO:0015030 IDA
    nuclear matrix GO:0016363 IDA
    neuronal cell body GO:0043025 IDA
    perikaryon GO:0043204 IDA
    extracellular exosome GO:0070062 IEA
    extracellular exosome GO:0070062 ISO
    extracellular exosome GO:0070062 ISS
    catalytic step 2 spliceosome GO:0071013 IBA
    catalytic step 2 spliceosome GO:0071013 IEA
    catalytic step 2 spliceosome GO:0071013 ISO
    neuronal ribonucleoprotein granule GO:0071598 IDA
    glutamatergic synapse GO:0098978 EXP
    glutamatergic synapse GO:0098978 IDA
    postsynaptic cytosol GO:0099524 IDA
    ribonucleoprotein complex GO:1990904 IEA
    ribonucleoprotein complex GO:1990904 ISO
    ribonucleoprotein complex GO:1990904 ISS
 Experiment description of studies that identified Hnrnpa2b1 in sEVs
1
Experiment ID 96
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 97
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Hnrnpa2b1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Sumo3  
Affinity Capture-MS Rattus norvegicus
2 Itm2b 290364
Affinity Capture-MS Rattus norvegicus
View the network image/svg+xml



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