Gene description for Rpl11
Gene name ribosomal protein L11
Gene symbol Rpl11
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Rpl11
ExoCarta ExoCarta_362631
Vesiclepedia VP_362631
Entrez Gene 362631
UniProt P62914  
 Rpl11 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
Hepatocytes 19367702    
 Gene ontology annotations for Rpl11
Molecular Function
    RNA binding GO:0003723 IBA
    structural constituent of ribosome GO:0003735 IBA
    structural constituent of ribosome GO:0003735 IEA
    structural constituent of ribosome GO:0003735 ISO
    5S rRNA binding GO:0008097 ISO
    ubiquitin protein ligase binding GO:0031625 ISO
    peroxisome proliferator activated receptor binding GO:0042975 IPI
    ubiquitin ligase inhibitor activity GO:1990948 ISO
Biological Process
    ribosomal large subunit assembly GO:0000027 ISO
    cytoplasmic translation GO:0002181 ISO
    rRNA processing GO:0006364 ISO
    translation GO:0006412 IBA
    translation GO:0006412 IEA
    protein targeting GO:0006605 ISO
    positive regulation of gene expression GO:0010628 ISO
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032435 ISO
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032435 ISS
    protein localization to nucleus GO:0034504 ISO
    protein localization to nucleus GO:0034504 ISS
    ribosomal large subunit biogenesis GO:0042273 ISO
    negative regulation of DNA-binding transcription factor activity GO:0043433 IDA
    protein stabilization GO:0050821 ISO
    translation at presynapse GO:0140236 NAS
    translation at postsynapse GO:0140242 NAS
    regulation of signal transduction by p53 class mediator GO:1901796 ISO
    positive regulation of signal transduction by p53 class mediator GO:1901798 ISO
    positive regulation of signal transduction by p53 class mediator GO:1901798 ISS
    negative regulation of ubiquitin protein ligase activity GO:1904667 ISO
    negative regulation of ubiquitin-dependent protein catabolic process GO:2000059 ISO
    negative regulation of protein neddylation GO:2000435 ISO
Subcellular Localization
    nucleoplasm GO:0005654 ISO
    nucleoplasm GO:0005654 ISS
    nucleolus GO:0005730 ISO
    nucleolus GO:0005730 ISS
    cytoplasm GO:0005737 ISO
    ribosome GO:0005840 IEA
    ribosome GO:0005840 NAS
    large ribosomal subunit GO:0015934 ISO
    cytosolic large ribosomal subunit GO:0022625 IBA
    cytosolic large ribosomal subunit GO:0022625 IDA
    cytosolic large ribosomal subunit GO:0022625 ISO
    cytosolic ribosome GO:0022626 IDA
    cytosolic ribosome GO:0022626 ISO
    protein-containing complex GO:0032991 ISO
    synapse GO:0045202 EXP
    synapse GO:0045202 IDA
    cytoplasmic side of rough endoplasmic reticulum membrane GO:0098556 ISO
    presynapse GO:0098793 NAS
    postsynapse GO:0098794 NAS
    ribonucleoprotein complex GO:1990904 IEA
 Experiment description of studies that identified Rpl11 in sEVs
1
Experiment ID 225
MISEV standards
EM
Biophysical techniques
GAPDH|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 35
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|CD81|CD63
Enriched markers
HSPA5
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Rpl11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Snca  
Affinity Capture-MS Rattus norvegicus
2 Sumo3  
Affinity Capture-MS Rattus norvegicus
3 Itm2b 290364
Affinity Capture-MS Rattus norvegicus
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