Gene description for Rac1
Gene name	ras-related C3 botulinum toxin substrate 1
Gene symbol	Rac1
Other names/aliases	-
Species	Rattus norvegicus
Database cross references - Rac1
ExoCarta	ExoCarta_363875
Vesiclepedia	VP_363875
Entrez Gene	363875
UniProt	Q6RUV5
Rac1 identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Urine	20535238

Gene ontology annotations for Rac1

Molecular Function     GTPase activity GO:0003924 IBA     GTPase activity GO:0003924 IDA     GTPase activity GO:0003924 IEA     GTPase activity GO:0003924 ISO     G protein activity GO:0003925 ISO     protein binding GO:0005515 IPI     GTP binding GO:0005525 IBA     GTP binding GO:0005525 IDA     GTP binding GO:0005525 IEA     GTP binding GO:0005525 ISO     enzyme binding GO:0019899 ISO     protein kinase binding GO:0019901 IBA     protein kinase binding GO:0019901 IEA     protein kinase binding GO:0019901 IPI     protein kinase binding GO:0019901 ISO     GTP-dependent protein binding GO:0030742 ISO     small GTPase binding GO:0031267 IPI     thioesterase binding GO:0031996 IEA     thioesterase binding GO:0031996 ISO     histone deacetylase binding GO:0042826 IPI     protein-containing complex binding GO:0044877 IEA     protein-containing complex binding GO:0044877 ISO     Rho GDP-dissociation inhibitor binding GO:0051022 IPI     ATPase binding GO:0051117 IPI     membrane scission GTPase motor activity GO:1990606 IEA Biological Process     neuron migration GO:0001764 ISO     neuron migration GO:0001764 ISO     neuron migration GO:0001764 ISS     positive regulation of protein phosphorylation GO:0001934 ISO     positive regulation of protein phosphorylation GO:0001934 ISS     auditory receptor cell morphogenesis GO:0002093 ISO     mast cell chemotaxis GO:0002551 IMP     sphingosine-1-phosphate receptor signaling pathway GO:0003376 IEA     sphingosine-1-phosphate receptor signaling pathway GO:0003376 ISO     epithelial cell morphogenesis GO:0003382 ISO     endocytosis GO:0006897 ISO     phagocytosis, engulfment GO:0006911 ISO     chemotaxis GO:0006935 IMP     hyperosmotic response GO:0006972 ISO     cytoskeleton organization GO:0007010 ISO     actin filament organization GO:0007015 IBA     actin filament organization GO:0007015 IEA     actin filament organization GO:0007015 IMP     actin filament organization GO:0007015 ISO     actin filament organization GO:0007015 ISS     cell adhesion GO:0007155 ISO     establishment or maintenance of cell polarity GO:0007163 IBA     enzyme-linked receptor protein signaling pathway GO:0007167 ISO     G protein-coupled receptor signaling pathway GO:0007186 ISO     small GTPase-mediated signal transduction GO:0007264 IEA     small GTPase-mediated signal transduction GO:0007264 ISO     small GTPase-mediated signal transduction GO:0007264 ISO     axon guidance GO:0007411 ISO     motor neuron axon guidance GO:0008045 IBA     regulation of cell shape GO:0008360 IBA     regulation of cell size GO:0008361 IEA     regulation of cell size GO:0008361 ISO     regulation of lamellipodium assembly GO:0010591 ISO     positive regulation of lamellipodium assembly GO:0010592 IEA     positive regulation of lamellipodium assembly GO:0010592 IMP     positive regulation of lamellipodium assembly GO:0010592 ISO     positive regulation of lamellipodium assembly GO:0010592 ISO     positive regulation of endothelial cell migration GO:0010595 IEA     positive regulation of endothelial cell migration GO:0010595 ISO     regulation of fibroblast migration GO:0010762 ISO     negative regulation of fibroblast migration GO:0010764 IEA     negative regulation of fibroblast migration GO:0010764 ISO     positive regulation of cell-substrate adhesion GO:0010811 ISO     regulation of neuron maturation GO:0014041 ISO     dendrite development GO:0016358 ISO     cell migration GO:0016477 IEA     cell migration GO:0016477 ISO     cell migration GO:0016477 ISO     Rac protein signal transduction GO:0016601 IBA     Rac protein signal transduction GO:0016601 ISO     Rac protein signal transduction GO:0016601 TAS     cerebral cortex radially oriented cell migration GO:0021799 ISO     embryonic olfactory bulb interneuron precursor migration GO:0021831 ISO     cerebral cortex GABAergic interneuron development GO:0021894 ISO     regulation of cell morphogenesis GO:0022604 ISO     cell projection assembly GO:0030031 IBA     lamellipodium assembly GO:0030032 IEA     lamellipodium assembly GO:0030032 ISO     lamellipodium assembly GO:0030032 ISO     actin cytoskeleton organization GO:0030036 IDA     actin cytoskeleton organization GO:0030036 ISO     actin filament polymerization GO:0030041 ISO     regulation of cell migration GO:0030334 ISO     regulation of cell migration GO:0030334 ISS     positive regulation of actin filament polymerization GO:0030838 ISO     cortical cytoskeleton organization GO:0030865 IBA     forebrain development GO:0030900 ISO     positive regulation of microtubule polymerization GO:0031116 IEA     positive regulation of microtubule polymerization GO:0031116 ISO     ruffle organization GO:0031529 ISO     response to lipopolysaccharide GO:0032496 ISO     negative regulation of interleukin-23 production GO:0032707 IEA     negative regulation of interleukin-23 production GO:0032707 ISO     regulation of actin cytoskeleton organization GO:0032956 IBA     substrate adhesion-dependent cell spreading GO:0034446 IEA     substrate adhesion-dependent cell spreading GO:0034446 ISO     substrate adhesion-dependent cell spreading GO:0034446 ISO     substrate adhesion-dependent cell spreading GO:0034446 ISS     non-canonical Wnt signaling pathway GO:0035567 ISO     positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 IMP     positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 ISO     erythrocyte enucleation GO:0043131 ISO     engulfment of apoptotic cell GO:0043652 ISO     cell-cell junction organization GO:0045216 ISO     regulation of nitric oxide biosynthetic process GO:0045428 IGI     bone resorption GO:0045453 IDA     positive regulation of DNA replication GO:0045740 IMP     regulation of receptor signaling pathway via JAK-STAT GO:0046425 ISO     hepatocyte growth factor receptor signaling pathway GO:0048012 IEA     hepatocyte growth factor receptor signaling pathway GO:0048012 ISO     regulation of neuronal synaptic plasticity GO:0048168 ISO     anatomical structure arrangement GO:0048532 ISO     neuron projection morphogenesis GO:0048812 ISO     dendrite morphogenesis GO:0048813 ISO     cell motility GO:0048870 ISO     cell motility GO:0048870 ISS     homeostasis of number of cells within a tissue GO:0048873 ISO     positive regulation of filopodium assembly GO:0051491 IMP     regulation of stress fiber assembly GO:0051492 ISO     positive regulation of stress fiber assembly GO:0051496 IEA     positive regulation of stress fiber assembly GO:0051496 ISO     localization within membrane GO:0051668 IEA     localization within membrane GO:0051668 ISO     positive regulation of focal adhesion assembly GO:0051894 IEA     positive regulation of focal adhesion assembly GO:0051894 ISO     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISO     synaptic transmission, GABAergic GO:0051932 ISO     Wnt signaling pathway, planar cell polarity pathway GO:0060071 ISO     regulation of respiratory burst GO:0060263 IEA     regulation of respiratory burst GO:0060263 ISO     cell chemotaxis GO:0060326 IBA     positive regulation of dendritic spine development GO:0060999 ISO     regulation of cell adhesion involved in heart morphogenesis GO:0061344 ISO     regulation of ERK5 cascade GO:0070376 ISO     cellular response to mechanical stimulus GO:0071260 IDA     semaphorin-plexin signaling pathway GO:0071526 IMP     dopaminergic neuron differentiation GO:0071542 ISO     protein localization to plasma membrane GO:0072659 ISO     angiotensin-activated signaling pathway involved in heart process GO:0086098 ISO     positive regulation of neutrophil chemotaxis GO:0090023 IEA     positive regulation of neutrophil chemotaxis GO:0090023 ISO     cochlea morphogenesis GO:0090103 ISO     ruffle assembly GO:0097178 IEA     ruffle assembly GO:0097178 ISO     postsynaptic actin cytoskeleton organization GO:0098974 EXP     postsynaptic actin cytoskeleton organization GO:0098974 IDA     postsynaptic actin cytoskeleton organization GO:0098974 IMP     regulation of postsynapse assembly GO:0150052 ISO     positive regulation of substrate adhesion-dependent cell spreading GO:1900026 IEA     positive regulation of substrate adhesion-dependent cell spreading GO:1900026 ISO     regulation of synaptic vesicle endocytosis GO:1900242 ISO     regulation of neutrophil migration GO:1902622 IBA     positive regulation of bicellular tight junction assembly GO:1903348 IEA     positive regulation of bicellular tight junction assembly GO:1903348 ISO     positive regulation of bicellular tight junction assembly GO:1903348 ISS     positive regulation of skeletal muscle acetylcholine-gated channel clustering GO:1904395 ISO     interneuron migration GO:1904936 ISO     midbrain dopaminergic neuron differentiation GO:1904948 ISO     positive regulation of ovarian follicle development GO:2000386 ISO     regulation of neuron migration GO:2001222 ISO Subcellular Localization     Golgi membrane GO:0000139 IDA     pericentriolar material GO:0000242 ISO     phagocytic cup GO:0001891 ISO     nucleus GO:0005634 IEA     nucleus GO:0005634 ISO     nucleus GO:0005634 ISS     cytoplasm GO:0005737 ISO     trans-Golgi network GO:0005802 IEA     trans-Golgi network GO:0005802 ISO     cytosol GO:0005829 IDA     cytoskeleton GO:0005856 IBA     actin filament GO:0005884 IEA     actin filament GO:0005884 ISO     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IEA     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 TAS     cell cortex GO:0005938 IEA     cell cortex GO:0005938 ISO     membrane GO:0016020 IDA     membrane GO:0016020 ISO     lamellipodium GO:0030027 IEA     lamellipodium GO:0030027 ISO     lamellipodium GO:0030027 ISS     dendrite GO:0030425 IEA     synaptic vesicle membrane GO:0030672 ISO     cytoplasmic vesicle GO:0031410 IBA     cytoplasmic vesicle GO:0031410 ISO     early endosome membrane GO:0031901 ISO     ruffle membrane GO:0032587 IEA     ruffle membrane GO:0032587 ISO     cytoplasmic ribonucleoprotein granule GO:0036464 IEA     cytoplasmic ribonucleoprotein granule GO:0036464 ISO     melanosome GO:0042470 IEA     presynaptic membrane GO:0042734 ISO     cell projection GO:0042995 ISO     dendritic spine GO:0043197 IBA     synapse GO:0045202 IEA     postsynaptic membrane GO:0045211 ISO     recycling endosome membrane GO:0055038 IEA     recycling endosome membrane GO:0055038 ISO     kinocilium GO:0060091 ISO     postsynapse GO:0098794 IEA     postsynapse GO:0098794 ISO     glutamatergic synapse GO:0098978 IEA     glutamatergic synapse GO:0098978 ISO     GABA-ergic synapse GO:0098982 EXP     GABA-ergic synapse GO:0098982 IDA     GABA-ergic synapse GO:0098982 IMP